Effect of Maternal Supplementation With Two Different Doses of Vitamin D During Lactation on Vitamin D Status, Anthropometry and Bone Mass of Infants: A Randomized Controlled Trial

Background There is a high prevalence of vitamin D deficiency (VDD) in exclusively breast-fed infants in the absence of appropriate vitamin D supplementation. Objective To evaluate the efficacy of two doses of maternal vitamin D supplementation on vitamin D levels of mother-infant pairs and to asses...

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Bibliographic Details
Published in:Indian pediatrics 2022-04, Vol.59 (4), p.276-282
Main Authors: Ramot, Rekha, Yadav, Swati, Vishnoi, S. K., Sharma, Pramod, Khadgawat, Rajesh, Jora, Rakesh
Format: Article
Language:English
Subjects:
Anthropometry
Breast Feeding
Dietary Supplements
Female
Humans
Infant
Lactation
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Research Paper
Vitamin D
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - epidemiology
Vitamins
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Summary:Background There is a high prevalence of vitamin D deficiency (VDD) in exclusively breast-fed infants in the absence of appropriate vitamin D supplementation. Objective To evaluate the efficacy of two doses of maternal vitamin D supplementation on vitamin D levels of mother-infant pairs and to assess its effect on growth parameters (weight, length and head circumference) and bone mass of infants. Study design Randomized controlled trial. Participants Lactating mother-infant pairs ( n =220). Intervention Maternal oral vitamin D supplementation in two doses (group 1: 1,20,000 IU/month and group 2: 12,000 IU/month) for 12 months. Main outcomes Maternal and infant serum 25OHD levels, and infants’ growth and bone mass. Results There was high prevalence of VDD at baseline in mothers (94%) as well as infants (98.5%), which was reduced to 43.1% in (mothers) and 46.5% in infants after 12 months. Significantly higher median (IQR) serum 25OHD levels (ng/mL) were observed among mothers in group 1 compared to group 2 [46 (17–159) vs 18 (6–64); P
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-022-2489-2