Qualitative and quantitative analysis of Alpiniae Oxyphyllae Fructus by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry

Alpiniae Oxyphyllae Fructus, as a homology of medicine and food, has been widely used in China for thousands of years. However, the existing qualitative and quantitative methods are difficult to evaluate the quality of Alpiniae Oxyphyllae Fructus samples from multiple sources. In this paper, an high...

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Bibliographic Details
Published in:Journal of separation science 2022-03, Vol.45 (6), p.1185-1194
Main Authors: Zhang, Yu, Dong, Lei, Zhang, Qingyu, Han, Jing, Sui, Wenwen, Wei, Ziyun, Zhang, Zan, Tong, Yichen, Wang, Sijie, Han, Fei
Format: Article
Language:English
Subjects:
Chemical composition
Chromatography
Chromatography, High Pressure Liquid - methods
Cyclotron resonance
Cyclotrons
Drugs, Chinese Herbal - analysis
fingerprint
Fingerprints
Fourier Analysis
Fourier transforms
Fruit - chemistry
Homology
Ions
Liquid chromatography
Mass Spectrometry
Qualitative analysis
Quality assessment
Quantitative analysis
Scientific imaging
Spectroscopy
Traditional Chinese medicine
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Summary:Alpiniae Oxyphyllae Fructus, as a homology of medicine and food, has been widely used in China for thousands of years. However, the existing qualitative and quantitative methods are difficult to evaluate the quality of Alpiniae Oxyphyllae Fructus samples from multiple sources. In this paper, an high‐performance liquid chromatography fingerprint was established for assessing the quality of Alpiniae Oxyphyllae Fructus from different areas. Then, high‐performance liquid chromatography was coupled to Fourier transform‐ion cyclotron resonance mass spectrometry for characterization of the chemical compositions in Alpiniae Oxyphyllae Fructus. In fingerprint analysis, 54 common peaks were confirmed and six chromatographic peaks of them were identified. The similarity of 14 samples from different areas was between 0.990 and 1.000. Moreover, a total of 30 chemical components were characterized by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry method, six compounds of which were decisively identified. Finally, the content of nootkatone was determined by high‐performance liquid chromatography. In conclusion, the methods used in this study are efficient for qualitative and quantitative analysis of Alpiniae Oxyphyllae Fructus. Also, these methods can be used to control the quality of other traditional Chinese medicines.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.202100481