Ultra-High Signal Detection of Human Embryonic Stem Cells Driven by Two-Dimensional Materials

We observed a unique bioelectric signal of human embryonic stem cells using direct current–voltage measurements facilitated by few-layered 2D-MoS2 sheets. A 1.828 mA cell signal was achieved (2 orders of magnitude higher than previous electrical-based detection methods) as well as multiple cell read...

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Bibliographic Details
Published in:ACS applied bio materials 2018-08, Vol.1 (2), p.210-215
Main Authors: Chan, Sophia S. Y, Tan, Yaw Sing, Wu, Kan-Xing, Cheung, Christine, Loke, Desmond K
Format: Article
Language:English
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Summary:We observed a unique bioelectric signal of human embryonic stem cells using direct current–voltage measurements facilitated by few-layered 2D-MoS2 sheets. A 1.828 mA cell signal was achieved (2 orders of magnitude higher than previous electrical-based detection methods) as well as multiple cell reading cycles demonstrating I ∼ 1.9 mA. Native stem cell proliferation, viability, and pluripotency were preserved. Molecular dynamics simulations elucidated the origin of the 2D-MoS2 sheet-assisted increase in current flow. This paves the way for the development of a broadly applicable, fast, and damage-free stem cell detection method capable of identifying pluripotency with virtually any complementary-metal-oxide-semiconductor circuits.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.8b00085