Investigation of phenolic compounds at the leaves and shoots Arctostaphylos spp. and their antioxidant and antityrosinase activities

Comparative phytochemical and pharmacological analysis of leaves and shoots of (L.) Spreng. and endemic of Transcaucasia and North Caucasia Lipsch. was carried out. Phenolic compounds in methanol extracts were investigated by HPLC-PDA-ESI-MS. Pharmacological investigation was carried out at the mode...

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Bibliographic Details
Published in:Natural product research 2022-12, Vol.36 (24), p.1-6317
Main Authors: Shamilov, Arnold Alexeevich, Olennikov, Daniil Nikolaevich, Pozdnyakov, Dmitryi Igorevich, Bubenchikova, Valentina Nikolaevna, Garsiya, Ekaterina Robertovna
Format: Article
Language:English
Subjects:
Arctostaphylos
Ethanol
Free radicals
Leaves
Liquid chromatography
Pharmacology
Phenolic compounds
Phenols
Saponins
Shoots
Tyrosinase
Tyrosine
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Summary:Comparative phytochemical and pharmacological analysis of leaves and shoots of (L.) Spreng. and endemic of Transcaucasia and North Caucasia Lipsch. was carried out. Phenolic compounds in methanol extracts were investigated by HPLC-PDA-ESI-MS. Pharmacological investigation was carried out at the models of generation of superoxide, DPPH, hydroxyl and nitrosyl radicals. The antityrosinase properties were evaluated in the reaction of tyrosinase inhibition using L -tyrosine as a substrate. Five new compounds were identified in the shoots and leaves of : 4,6-di-О-galloylglucose; 2,3-di-О-galloylglucose; 1,4,6-tri-О-galloylglucose; 1,2,4,6-tetra-О-galloylglucose; tetra-О-galloylhexose. Thirty-five phenolic compounds and two saponins were identified for the first time in . Water-alcohol extract (70% ethanol) from had the highest antiradical activity. Water extracts from both species had antityrosinase activity and possessed comparable efficiency (IC = 36.4 ± 1.2 µg/ml and IC = 35,5 ± 2 µg/ml, respectively).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2025370