Biomaterial Applications in Islet Encapsulation and Transplantation

The worldwide prevalence of type 1 diabetes motivates the development of different treatment options for the disease. Current clinical treatments typically require patient involvement, often resulting in stress or inconvenience to the patient due to frequent blood glucose measurements and insulin in...

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Bibliographic Details
Published in:ACS applied bio materials 2020-12, Vol.3 (12), p.8127-8135
Main Authors: Caserto, Julia S, Bowers, Daniel T, Shariati, Kaavian, Ma, Minglin
Format: Article
Language:English
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Summary:The worldwide prevalence of type 1 diabetes motivates the development of different treatment options for the disease. Current clinical treatments typically require patient involvement, often resulting in stress or inconvenience to the patient due to frequent blood glucose measurements and insulin injections or infusions. Islet transplantation, a potentially curative treatment, is limited by donor availability and the need for long-term administration of immunosuppressants. Cell encapsulation may prevent graft rejection without immunosuppression, however, foreign body responses, mass transfer limitations, scalability, and safety are all significant challenges. This Spotlight paper summarizes our recent efforts to address these challenges including developing biomaterials to mitigate foreign body responses and fibrosis, engineering scalable and retrievable encapsulation devices, as well as designing oxygen supplementation and vascularization strategies.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.0c01235