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The diagnostic value of contrast enhancement on MRI in diffuse and anaplastic gliomas
Purpose We evaluated differentiations in gadolinium contrast enhancement (CE) between low-grade WHO °II and high-grade WHO °III gliomas in conventional MRI, which have been repeatedly questioned. Methods Ninety-nine patients, who underwent first resection of WHO°II and °III gliomas, were retrospecti...
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| Published in: | Acta neurochirurgica 2022-08, Vol.164 (8), p.2035-2040 |
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| container_title | Acta neurochirurgica |
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| creator | Krigers, Aleksandrs Demetz, Matthias Grams, Astrid E. Thomé, Claudius Freyschlag, Christian F. |
| description | Purpose
We evaluated differentiations in gadolinium contrast enhancement (CE) between low-grade WHO °II and high-grade WHO °III gliomas in conventional MRI, which have been repeatedly questioned.
Methods
Ninety-nine patients, who underwent first resection of WHO°II and °III gliomas, were retrospectively retrieved from a prospective database. The quantitative metric volume of Gd-CE in T1-weighted pre-operative MRI was measured using volumetric segmentation.
Results
The OR to detect CE in anaplastic gliomas was seven times higher than that in diffuse gliomas (CI95% 2.8–17.2,
p<
0.0001). No CE was seen in 50% (8/16) of focal anaplastic and in 28% (10/36) of entirely anaplastic gliomas. CE was present in 21% (10/47) of diffuse gliomas. Anaplasia correlated with a larger CE volume (
r=
0.49,
p<
0.0001) and provided additional 4 cm
3
of CE volume compared to entirely diffuse tumors. The OR to have CE was 3.6 times for IDH1 wild-type tumors (CI95% 1.3–10.2,
p=
0.05) and 4.8 for tumors with ATRX expression (CI95% 1.3–17.2,
p=
0.05). In all sub-groups, at least a quarter of cases showed no CE at all and there were cases with present CE.
Conclusion
CE is associated with higher odds of unfavorable prognostic features like anaplasia, wild-type IDH1 and retained ATRX. There was no CE in one-fourth of anaplastic gliomas and half of gliomas with focal anaplasia. |
| doi_str_mv | 10.1007/s00701-021-05103-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2619217086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2696321759</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-b1095625b1b3bdf82578d1a127684451feca7bdf26203252e5a4e3c8a2e50dc83</originalsourceid><addsrcrecordid>eNp9kElPwzAQhS0EoqXwBzggS1y4BLzEWY4IsVQqQkLt2XKcSZsqsYudIPHvcZuyiAOHGY803zw_PYTOKbmmhKQ3PjRCI8JCCUp4lB2gMcljFoVGDn_NI3Ti_ZoQytKYH6MRF4RmgtMxWsxXgMtaLY31Xa3xu2p6wLbC2prOKd9hMCtlNLRgOmwNfn6d4tqEk6rqPWBlylBq06jd-bKpbav8KTqqVOPhbP9O0OLhfn73FM1eHqd3t7NI81R0UUFJLhImClrwoqwyJtKspCq4TLI4FrQCrdKwYAkjnAkGQsXAdabCREqd8Qm6GnQ3zr714DvZ1l5D0ygDtveSJTRnNCVZEtDLP-ja9s4Ed4HKEx4wkQeKDZR21nsHldy4ulXuQ1Iit6HLIXQZQpe70OXWxcVeui9aKL9PvlIOAB8AH1ZmCe7n739kPwEf24sd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2696321759</pqid></control><display><type>article</type><title>The diagnostic value of contrast enhancement on MRI in diffuse and anaplastic gliomas</title><source>Springer Link</source><creator>Krigers, Aleksandrs ; Demetz, Matthias ; Grams, Astrid E. ; Thomé, Claudius ; Freyschlag, Christian F.</creator><creatorcontrib>Krigers, Aleksandrs ; Demetz, Matthias ; Grams, Astrid E. ; Thomé, Claudius ; Freyschlag, Christian F.</creatorcontrib><description>Purpose
We evaluated differentiations in gadolinium contrast enhancement (CE) between low-grade WHO °II and high-grade WHO °III gliomas in conventional MRI, which have been repeatedly questioned.
Methods
Ninety-nine patients, who underwent first resection of WHO°II and °III gliomas, were retrospectively retrieved from a prospective database. The quantitative metric volume of Gd-CE in T1-weighted pre-operative MRI was measured using volumetric segmentation.
Results
The OR to detect CE in anaplastic gliomas was seven times higher than that in diffuse gliomas (CI95% 2.8–17.2,
p<
0.0001). No CE was seen in 50% (8/16) of focal anaplastic and in 28% (10/36) of entirely anaplastic gliomas. CE was present in 21% (10/47) of diffuse gliomas. Anaplasia correlated with a larger CE volume (
r=
0.49,
p<
0.0001) and provided additional 4 cm
3
of CE volume compared to entirely diffuse tumors. The OR to have CE was 3.6 times for IDH1 wild-type tumors (CI95% 1.3–10.2,
p=
0.05) and 4.8 for tumors with ATRX expression (CI95% 1.3–17.2,
p=
0.05). In all sub-groups, at least a quarter of cases showed no CE at all and there were cases with present CE.
Conclusion
CE is associated with higher odds of unfavorable prognostic features like anaplasia, wild-type IDH1 and retained ATRX. There was no CE in one-fourth of anaplastic gliomas and half of gliomas with focal anaplasia.</description><identifier>ISSN: 0942-0940</identifier><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-021-05103-8</identifier><identifier>PMID: 35018531</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Age ; Gadolinium ; Glioma ; Image processing ; Interventional Radiology ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Minimally Invasive Surgery ; Nervous system ; Neurology ; Neuropathology ; Neuroradiology ; Neurosurgery ; Normal distribution ; Original Article - Tumor - Glioma ; Segmentation ; Surgical Orthopedics ; Tumor – Glioma ; Tumors</subject><ispartof>Acta neurochirurgica, 2022-08, Vol.164 (8), p.2035-2040</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b1095625b1b3bdf82578d1a127684451feca7bdf26203252e5a4e3c8a2e50dc83</citedby><cites>FETCH-LOGICAL-c375t-b1095625b1b3bdf82578d1a127684451feca7bdf26203252e5a4e3c8a2e50dc83</cites><orcidid>0000-0002-0950-426X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35018531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krigers, Aleksandrs</creatorcontrib><creatorcontrib>Demetz, Matthias</creatorcontrib><creatorcontrib>Grams, Astrid E.</creatorcontrib><creatorcontrib>Thomé, Claudius</creatorcontrib><creatorcontrib>Freyschlag, Christian F.</creatorcontrib><title>The diagnostic value of contrast enhancement on MRI in diffuse and anaplastic gliomas</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Purpose
We evaluated differentiations in gadolinium contrast enhancement (CE) between low-grade WHO °II and high-grade WHO °III gliomas in conventional MRI, which have been repeatedly questioned.
Methods
Ninety-nine patients, who underwent first resection of WHO°II and °III gliomas, were retrospectively retrieved from a prospective database. The quantitative metric volume of Gd-CE in T1-weighted pre-operative MRI was measured using volumetric segmentation.
Results
The OR to detect CE in anaplastic gliomas was seven times higher than that in diffuse gliomas (CI95% 2.8–17.2,
p<
0.0001). No CE was seen in 50% (8/16) of focal anaplastic and in 28% (10/36) of entirely anaplastic gliomas. CE was present in 21% (10/47) of diffuse gliomas. Anaplasia correlated with a larger CE volume (
r=
0.49,
p<
0.0001) and provided additional 4 cm
3
of CE volume compared to entirely diffuse tumors. The OR to have CE was 3.6 times for IDH1 wild-type tumors (CI95% 1.3–10.2,
p=
0.05) and 4.8 for tumors with ATRX expression (CI95% 1.3–17.2,
p=
0.05). In all sub-groups, at least a quarter of cases showed no CE at all and there were cases with present CE.
Conclusion
CE is associated with higher odds of unfavorable prognostic features like anaplasia, wild-type IDH1 and retained ATRX. There was no CE in one-fourth of anaplastic gliomas and half of gliomas with focal anaplasia.</description><subject>Age</subject><subject>Gadolinium</subject><subject>Glioma</subject><subject>Image processing</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally Invasive Surgery</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuropathology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Normal distribution</subject><subject>Original Article - Tumor - Glioma</subject><subject>Segmentation</subject><subject>Surgical Orthopedics</subject><subject>Tumor – Glioma</subject><subject>Tumors</subject><issn>0942-0940</issn><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kElPwzAQhS0EoqXwBzggS1y4BLzEWY4IsVQqQkLt2XKcSZsqsYudIPHvcZuyiAOHGY803zw_PYTOKbmmhKQ3PjRCI8JCCUp4lB2gMcljFoVGDn_NI3Ti_ZoQytKYH6MRF4RmgtMxWsxXgMtaLY31Xa3xu2p6wLbC2prOKd9hMCtlNLRgOmwNfn6d4tqEk6rqPWBlylBq06jd-bKpbav8KTqqVOPhbP9O0OLhfn73FM1eHqd3t7NI81R0UUFJLhImClrwoqwyJtKspCq4TLI4FrQCrdKwYAkjnAkGQsXAdabCREqd8Qm6GnQ3zr714DvZ1l5D0ygDtveSJTRnNCVZEtDLP-ja9s4Ed4HKEx4wkQeKDZR21nsHldy4ulXuQ1Iit6HLIXQZQpe70OXWxcVeui9aKL9PvlIOAB8AH1ZmCe7n739kPwEf24sd</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Krigers, Aleksandrs</creator><creator>Demetz, Matthias</creator><creator>Grams, Astrid E.</creator><creator>Thomé, Claudius</creator><creator>Freyschlag, Christian F.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0950-426X</orcidid></search><sort><creationdate>20220801</creationdate><title>The diagnostic value of contrast enhancement on MRI in diffuse and anaplastic gliomas</title><author>Krigers, Aleksandrs ; Demetz, Matthias ; Grams, Astrid E. ; Thomé, Claudius ; Freyschlag, Christian F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-b1095625b1b3bdf82578d1a127684451feca7bdf26203252e5a4e3c8a2e50dc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Gadolinium</topic><topic>Glioma</topic><topic>Image processing</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minimally Invasive Surgery</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuropathology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Normal distribution</topic><topic>Original Article - Tumor - Glioma</topic><topic>Segmentation</topic><topic>Surgical Orthopedics</topic><topic>Tumor – Glioma</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krigers, Aleksandrs</creatorcontrib><creatorcontrib>Demetz, Matthias</creatorcontrib><creatorcontrib>Grams, Astrid E.</creatorcontrib><creatorcontrib>Thomé, Claudius</creatorcontrib><creatorcontrib>Freyschlag, Christian F.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krigers, Aleksandrs</au><au>Demetz, Matthias</au><au>Grams, Astrid E.</au><au>Thomé, Claudius</au><au>Freyschlag, Christian F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnostic value of contrast enhancement on MRI in diffuse and anaplastic gliomas</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>164</volume><issue>8</issue><spage>2035</spage><epage>2040</epage><pages>2035-2040</pages><issn>0942-0940</issn><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>Purpose
We evaluated differentiations in gadolinium contrast enhancement (CE) between low-grade WHO °II and high-grade WHO °III gliomas in conventional MRI, which have been repeatedly questioned.
Methods
Ninety-nine patients, who underwent first resection of WHO°II and °III gliomas, were retrospectively retrieved from a prospective database. The quantitative metric volume of Gd-CE in T1-weighted pre-operative MRI was measured using volumetric segmentation.
Results
The OR to detect CE in anaplastic gliomas was seven times higher than that in diffuse gliomas (CI95% 2.8–17.2,
p<
0.0001). No CE was seen in 50% (8/16) of focal anaplastic and in 28% (10/36) of entirely anaplastic gliomas. CE was present in 21% (10/47) of diffuse gliomas. Anaplasia correlated with a larger CE volume (
r=
0.49,
p<
0.0001) and provided additional 4 cm
3
of CE volume compared to entirely diffuse tumors. The OR to have CE was 3.6 times for IDH1 wild-type tumors (CI95% 1.3–10.2,
p=
0.05) and 4.8 for tumors with ATRX expression (CI95% 1.3–17.2,
p=
0.05). In all sub-groups, at least a quarter of cases showed no CE at all and there were cases with present CE.
Conclusion
CE is associated with higher odds of unfavorable prognostic features like anaplasia, wild-type IDH1 and retained ATRX. There was no CE in one-fourth of anaplastic gliomas and half of gliomas with focal anaplasia.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>35018531</pmid><doi>10.1007/s00701-021-05103-8</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0950-426X</orcidid></addata></record> |
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| subjects | Age Gadolinium Glioma Image processing Interventional Radiology Magnetic resonance imaging Medicine Medicine & Public Health Minimally Invasive Surgery Nervous system Neurology Neuropathology Neuroradiology Neurosurgery Normal distribution Original Article - Tumor - Glioma Segmentation Surgical Orthopedics Tumor – Glioma Tumors |
| title | The diagnostic value of contrast enhancement on MRI in diffuse and anaplastic gliomas |
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