Oleuropein suppresses mitochondrial reactive oxygen species generation possibly via an activation of transient receptor potential V1 and sirtuin‐1 in cultured chicken muscle cells

This study investigated the intracellular mechanism governing the effects of oleuropein (OLE), a phenolic compound of Olea europaea, on mRNA expression of avian uncoupling protein (avUCP) and mitochondrial biogenesis‐related factors, and reactive oxygen species (mitROS) generation in a primary cultu...

Full description

Saved in:
Bibliographic Details
Published in:Animal science journal 2022-01, Vol.93 (1), p.e13677-n/a
Main Authors: Muroi, Hikaru, Hori, Kouhei, Tokutake, Yukako, Hakamata, Yuki, Kawabata, Fuminori, Toyomizu, Masaaki, Kikusato, Motoi
Format: Article
Language:English
Subjects:
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
avian UCP
Calcium (intracellular)
Calcium (reticular)
calcium influx
Calcium ions
Capsaicin receptors
Cell membranes
Chickens
Chickens - metabolism
Cultured meat
Endoplasmic reticulum
Gene expression
Inhibitors
Intracellular
Iridoid Glucosides
Kinases
Muscle Cells - metabolism
Muscle, Skeletal - metabolism
Muscles
Oleuropein
Oxygen
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
PGC‐1α
Phenolic compounds
Phenols
Phosphorylation
Proteins
Reactive Oxygen Species
Receptors
SIRT1 protein
Sirtuin 1 - genetics
Sirtuin 1 - metabolism
Transient receptor potential proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study investigated the intracellular mechanism governing the effects of oleuropein (OLE), a phenolic compound of Olea europaea, on mRNA expression of avian uncoupling protein (avUCP) and mitochondrial biogenesis‐related factors, and reactive oxygen species (mitROS) generation in a primary cultured chicken muscle cells. The OLE‐treated cells exhibited increases in Avucp and ATP5a1z expression and a decrease in mitROS generation (p 
ISSN:1344-3941
1740-0929
DOI:10.1111/asj.13677