Significant Enhancement of Antimicrobial Activity in Oxygen-Deficient Zinc Oxide Nanowires

• Published in: ACS applied bio materials 2020-05, Vol.3 (5), p.2997-3004
• Main Authors: Elbourne, Aaron, Cheeseman, Samuel, Wainer, Pierce, Kim, Jaewon, Medvedev, Alexander E, Boyce, Kylie. J, McConville, Christopher F, van Embden, Joel, Crawford, Russell J, Chapman, James, Truong, Vi Khanh, Della Gaspera, Enrico
• Format: Article
• Language: English
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.0c00065

The fabrication of antimicrobial surfaces that exhibit enhanced activity toward a large variety of microbial species is one of the major challenges of our time. In fact, the negative effects associated with both bacterial and fungal infections are enormous, especially considering that many microbial species are developing resistance to known antibiotics. In this work, we show how a combination of a specific surface morphology and surface chemistry can create a surface that exhibits nearly 100% antimicrobial activity toward both Gram-negative and Gram-positive bacteria and fungal cells. Arrays of vertically aligned, oxygen-deficient zinc oxide (ZnO) nanowires grown on a substrate exhibit enhanced antimicrobial activity compared with surfaces containing either less defective nanowires or highly oxygen-deficient flat films. This synergistic effect between physical activity (morphology) and chemical activity (surface composition) has been shown to be responsible for the outstanding antimicrobial activity of our surfaces, especially toward notoriously resilient bacterial or fungal species. These findings provide a series of design rules for tuning the activities of antibacterial and antifungal nanomaterials. These rules constitute an excellent platform for the development of next-generation antimicrobial surfaces.