Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands

Singlet oxygen is the primary agent responsible for the therapeutic effects of photodynamic therapy (PDT). In this work, we demonstrate that singlet oxygen release due to thermal endoperoxide cycloreversion can be targeted towards specific features of selected cancer cells, and this targeted singlet...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-02, Vol.58 (12), p.1902-1905
Main Authors: Wang, Lei, Tang, Lei, Liu, Yingjie, Wu, Hao, Liu, Ziang, Li, Jin, Pan, Yue, Akkaya, Engin U
Format: Article
Language:English
Subjects:
Antigens
Antigens, Surface - drug effects
Cancer
Cell Line, Tumor
Chemical compounds
Glutamate Carboxypeptidase II - drug effects
Humans
Ligands
Male
Membranes
Pharmacology
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Prostate
Prostatic Neoplasms - drug therapy
Singlet oxygen
Singlet Oxygen - administration & dosage
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Summary:Singlet oxygen is the primary agent responsible for the therapeutic effects of photodynamic therapy (PDT). In this work, we demonstrate that singlet oxygen release due to thermal endoperoxide cycloreversion can be targeted towards specific features of selected cancer cells, and this targeted singlet oxygen delivery can serve as an effective therapeutic tool. Thus, cytotoxic singlet oxygen can be delivered regioselectively into prostate specific membrane antigen (PSMA) overexpressing lymph node carcinoma (LNCaP) cells. However, unlike typical photodynamic processes, there is no need for light or oxygen. The potential of the approach is exciting, considering the limitations on the availability of light and oxygen in deep-seated tumors.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc05810j