Laser-photobiomodulation on titanium implant bone healing in rat model: comparison between 660- and 808-nm wavelength

Laser-photobiomodulation (L-PBM) has been widely studied and its biomodulatory effects have been established on irradiated cells, increasing viability and proliferation and on damaged tissues. In addition, L-PBM may reduce and modulate the inflammatory process. The effect of 660-nm and 808-nm laser-...

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Bibliographic Details
Published in:Lasers in medical science 2022-06, Vol.37 (4), p.2179-2184
Main Authors: da Fonseca, Guilherme Aparecido Monteiro Duque, Cavalcanti, Marcos Fernando Xisto Braga, de Souza Maior, José Daniel, da Silva Pereira, Juliana, Pinto, Leandro augusto, Matias, Murilo, Frigo, Lucio
Format: Article
Language:English
Subjects:
Animal models
Animals
Bone healing
Bone histomorphometry
Bone implants
Bone matrix
Cell proliferation
Dental implants
Dental prosthetics
Dentistry
Femur
Inflammation
Infrared analysis
Irradiation
Lasers
Light therapy
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Photonics
Quantum Optics
Radiation damage
Subgroups
Titanium
Transplants & implants
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Summary:Laser-photobiomodulation (L-PBM) has been widely studied and its biomodulatory effects have been established on irradiated cells, increasing viability and proliferation and on damaged tissues. In addition, L-PBM may reduce and modulate the inflammatory process. The effect of 660-nm and 808-nm laser-photobiomodulation on bone repair around titanium dental implants placed in rat’s femur was evaluated by histomorphometry. Twenty-seven Wistar rats were divided into 3 groups of nine animals: group C — non-irradiated control; group R — λ =660nm irradiated; and group IR — λ =808nm irradiated. Each group was further divided in 3 subgroups of three animals each, according to histomorphometry analysis in 3 days, 7 days, and 14 days after irradiation. Histological H.E.-stained slides were photographed, and bone matrix measured in new-formed bone area. Bone matrix histomorphometry analysis indicates that at 7 days in the irradiated groups (R and IR), a bigger area matrix was observed in relation to control group (C) ( p =0.04 and p =0.048 respectively). On the other hand, at 14 days, control group (C) presented a bigger area than infrared irradiated (IR) ( p =0.001) and red irradiated group (R) also showed a bigger area than infrared irradiated group (IR) ( p =0.019). Histological analysis indicates that irradiated groups (R and IR) exhibited a faster bone tissue matrix production than control group Graphical abstract
ISSN:1435-604X
0268-8921
1435-604X
DOI:10.1007/s10103-021-03481-0