Anti-inflammatory Dimeric Tetrahydroxanthones from an Endophytic Muyocopron laterale

Twelve new dimeric tetrahydroxanthones, muyocoxanthones A–L (1–12), were isolated from the endophytic fungus, Muyocopron laterale. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of 1–10 and 12 were unambiguously determined...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2022-01, Vol.85 (1), p.148-161
Main Authors: Cao, Hai-Yan, Yi, Cheng, Sun, Sen-Feng, Li, Yong, Liu, Yun-Bao
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Ascomycota - chemistry
Carbon-13 Magnetic Resonance Spectroscopy
Crystallography, X-Ray - methods
Dimerization
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - metabolism
Mice
Nitric Oxide - biosynthesis
Proton Magnetic Resonance Spectroscopy
RAW 264.7 Cells
Spectrometry, Mass, Electrospray Ionization - methods
Xanthones - pharmacology
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Summary:Twelve new dimeric tetrahydroxanthones, muyocoxanthones A–L (1–12), were isolated from the endophytic fungus, Muyocopron laterale. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of 1–10 and 12 were unambiguously determined by ECD spectrum data and single-crystal X-ray diffraction analysis. Compounds 2, 6, and 11 showed inhibitory activity against the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 5.2, 1.3, and 5.1 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.1c00878