Role of Thioredoxin-1 and its inducers in human health and diseases

Thioredoxin-1 (Trx-1) is a small redox-active protein normally found in mammalian cells that responds to the changing redox environment by contributing electrons or regulating related proteins. There is growing evidence that Trx-1 has multiple functions, including cytoprotective, anti-apoptotic, ant...

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Bibliographic Details
Published in:European journal of pharmacology 2022-03, Vol.919, p.174756-174756, Article 174756
Main Authors: Liu, Yuanyuan, Xue, Nianyu, Zhang, Boxi, Lv, Hongming, Li, Shize
Format: Article
Language:English
Subjects:
Antioxidant
Antioxidants - metabolism
Cerebral ischemia
Coronary Artery Disease - metabolism
Humans
Inducers
Nitrosation
Thioredoxin-1 (Trx-1)
Thioredoxins - metabolism
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Summary:Thioredoxin-1 (Trx-1) is a small redox-active protein normally found in mammalian cells that responds to the changing redox environment by contributing electrons or regulating related proteins. There is growing evidence that Trx-1 has multiple functions, including cytoprotective, anti-apoptotic, antioxidant and anti-inflammatory effects. To date, researchers have found that Trx-1 deficiency leads to severe damage in various disease models, such as atherosclerosis, cerebral ischemia, diabetes and tumors. Conversely, activation of Trx-1 has a protective effect against these diseases. Accordingly, a variety of Trx-1 inducers have been widely used in the clinic with significant therapeutic value. In this paper, we summarize the pathogenesis of Trx-1 involvement in the above-mentioned diseases and describe the protective effects of Trx-1 inducers on them.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2022.174756