MiRNA21 and IL-18 levels in left atrial blood in patients with atrial fibrillation undergoing cryoablation and their predictive value for recurrence of atrial fibrillation

Purpose The recurrence of atrial fibrillation (AF) after cryoablation still needs to be prioritized, including discriminating predictive indicators. Methods Eighty-seven patients aged 43–83 years who underwent cryo-balloon ablation were divided into paroxysmal atrial fibrillation (PAF) and non-parox...

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Published in:Journal of interventional cardiac electrophysiology 2022-06, Vol.64 (1), p.111-120
Main Authors: Liu, Yanhong, Luo, Di, Liu, Enzhao, Liu, Tong, Xu, Gang, Liang, Xue, Yuan, Meng, Zhang, Yue, Chen, Xinpei, Chen, Xu, Miao, Shuai, Shangguan, Wenfeng, Li, Guangping
Format: Article
Language:English
Subjects:
Ablation
Atrial Fibrillation
Biomarkers
Blood
Cardiac arrhythmia
Cardiology
Catheter Ablation
Cryosurgery
Fibrillation
Humans
Indicators
Interleukin 18
Medicine
Medicine & Public Health
MicroRNAs - genetics
Peripheral blood
Recurrence
Treatment Outcome
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Summary:Purpose The recurrence of atrial fibrillation (AF) after cryoablation still needs to be prioritized, including discriminating predictive indicators. Methods Eighty-seven patients aged 43–83 years who underwent cryo-balloon ablation were divided into paroxysmal atrial fibrillation (PAF) and non-paroxysmal atrial fibrillation (non-PAF) groups. Baseline data, intraoperative index, and miRNA21, IL-18, NLRP3, and visfatin levels in peripheral venous blood and left atrial blood were assessed. Follow-up was performed for 6 months to observe the recurrence of AF. A Cox risk ratio model was used to analyze indicators for predicting AF recurrence. Results The non-PAF and PAF group recurrence rates of AF were statistically different ( p  
ISSN:1383-875X
1572-8595
DOI:10.1007/s10840-022-01125-z