Nitrogen-Doped Carbon Dots via Hydrothermal Synthesis: Naked Eye Fluorescent Sensor for Dopamine and Used for Multicolor Cell Imaging

The development of a novel uncomplicated sensor for sensitive and selective detection in biomedical analysis is necessary. This study demonstrates the preparation of nitrogen-doped carbon dots (NC dots) via hydrothermal synthesis as a naked eye fluorescent probe for selective and sensitive detectio...

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Bibliographic Details
Published in:ACS applied bio materials 2019-05, Vol.2 (5), p.2069-2077
Main Authors: Naik, Vaibhav, Zantye, Pranjita, Gunjal, Datta, Gore, Anil, Anbhule, Prashant, Kowshik, Meenal, Bhosale, Sheshanath V, Kolekar, Govind
Format: Article
Language:English
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Summary:The development of a novel uncomplicated sensor for sensitive and selective detection in biomedical analysis is necessary. This study demonstrates the preparation of nitrogen-doped carbon dots (NC dots) via hydrothermal synthesis as a naked eye fluorescent probe for selective and sensitive detection of dopamine (DA). The successful synthesis of NC dots was confirmed using various microscopic and spectroscopic techniques. In addition, NC-dot-incorporated gel strips were prepared through a simple approach for naked eye detection of dopamine. The linear range for detection of dopamine was 2–20 μg/mL with a detection limit as low as 1.97 μg/mL. Moreover, NC dots showed a low toxicity toward HeLa cells, demonstrating their relevance in multicolor cell imaging. The developed probe was also utilized for quantitative determination of dopamine in a commercial pharmaceutical sample with adequate results.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.9b00101