Ubiquitination regulation of aerobic glycolysis in cancer

Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic reprogramming and plays a crucial role in the occurrence and development of tumours. Ubiquitination and deubiquitination, essential post-translational modifications, have attracted increasing attention with regard...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2022-03, Vol.292, p.120322-120322, Article 120322
Main Authors: Xie, Yao, Wang, Mu, Xia, Min, Guo, Yinping, Zu, Xuyu, Zhong, Jing
Format: Article
Language:English
Subjects:
Aerobic glycolysis
Cancer
Deubiquitination
Glycolysis
Humans
Metabolic reprogramming
Metabolism
Neoplasms - metabolism
Post-translation
Signal transduction
Transcription factors
Tumors
Ubiquitination
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic reprogramming and plays a crucial role in the occurrence and development of tumours. Ubiquitination and deubiquitination, essential post-translational modifications, have attracted increasing attention with regards to the regulation of metabolic reprogramming in cancer. However, the mechanism of ubiquitination in glycolysis remains unclear. In this review, we discuss the roles of ubiquitination and deubiquitination in regulating glycolysis, and their involvement in regulating important signalling pathways, enzymes, and transcription factors. Focusing on potential mechanisms may provide novel strategies for cancer treatment. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2022.120322