Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background

• Published in: Journal of cancer research and clinical oncology 2022-05, Vol.148 (5), p.1063-1071
• Main Authors: Honma, Naoko, Arai, Tomio, Matsuda, Yoko, Fukunaga, Yosuke, Akishima-Fukasawa, Yuri, Yamamoto, Noriko, Kawachi, Hiroshi, Ishikawa, Yuichi, Takeuchi, Kengo, Mikami, Tetuo
• Format: Article
• Language: English
• Subjects: 17β-Estradiol; Age; Cancer Research; Chromatography, Liquid; Colon cancer; Colonic Neoplasms; Colorectal cancer; Colorectal carcinoma; Epithelium; Estradiol - analysis; Estrogen Receptor beta; Estrogen receptors; Estrogens; Estrogens - analysis; Estrone; Female; Hematology; Histology; Humans; Internal Medicine; Liquid chromatography; Mass spectroscopy; Medicine; Medicine & Public Health; Mismatch repair; Oncology; Original Article – Cancer Research; Patients; Post-menopause; Postmenopause; Receptors, Estrogen - metabolism; Tandem Mass Spectrometry; Tumors
• ISSN: 0171-5216; 1432-1335
• DOI: 10.1007/s00432-021-03889-9

Purpose A large number of studies have suggested an inhibitory role of estrogens against colorectal cancer (CRC), but persistent controversy exists. CRC characteristics are affected by sex, age, and tumor locus, suggesting the need for a systematic study considering these factors. The purpose of this study was to verify the difference in the pathobiological role of estrogens in CRC according to patient/tumor backgrounds. Methods Surgical specimens from 116 postmenopausal women (≥ 70 years/o, n  = 74;