Recent advances in induced proximity modalities

Challenging disease targets necessitate new approaches for therapeutic intervention. Rewiring protein-biomolecule interactions with proximity-inducing agents extends intervention opportunities beyond target agonism or inhibition. Spanning varied molecular phenotypes and diverse target classes, proxi...

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Bibliographic Details
Published in:Current opinion in chemical biology 2022-04, Vol.67, p.102107-102107, Article 102107
Main Authors: Ng, Christine S.C., Banik, Steven M.
Format: Article
Language:English
Subjects:
Biologics
CRISPR
LYTAC
Molecular glue
PROTAC
Protein Processing, Post-Translational
Proteolysis
Proteomics
Proximity
RIPR
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Summary:Challenging disease targets necessitate new approaches for therapeutic intervention. Rewiring protein-biomolecule interactions with proximity-inducing agents extends intervention opportunities beyond target agonism or inhibition. Spanning varied molecular phenotypes and diverse target classes, proximity-inducing agents demonstrate immense potential across target degradation, cleavage, and post-translational editing. Here, we review a selection of exciting developments in the concepts and mechanisms of induced proximity-driven strategies from the last two years. Key technological advances that enable these discoveries and expand the scope of targets and machinery for induced-proximity modalities are highlighted.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2021.102107