Heterogeneous catalyst SiO2–LaCl3·7H2O: characterization and microwave-assisted green synthesis of α-aminophosphonates and their antimicrobial activity

Silica-supported lanthanum (III) chloride (SiO 2 –LaCl 3 ·7H 2 O) was prepared and characterized by infrared spectroscopy, X-ray diffraction analysis, scanning electron microscope, energy-dispersive X-ray spectroscopy, thermogravimetric analysis and differential thermal analysis techniques. The cata...

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Bibliographic Details
Published in:Molecular diversity 2022-10, Vol.26 (5), p.2703-2715
Main Authors: Basha, S. K. Thaslim, Kalla, Reddi Mohan Naidu, Varalakshmi, M., Sudhamani, H., Appa, Rama Moorthy, Chul Hong, Sung, Raju, Chamarthi Naga
Format: Article
Language:English
Subjects:
Antimicrobial agents
Biochemistry
Biomedical and Life Sciences
Chloride
Enzymes
Fourier transforms
Life Sciences
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
Solvents
Thermogravimetric analysis
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Summary:Silica-supported lanthanum (III) chloride (SiO 2 –LaCl 3 ·7H 2 O) was prepared and characterized by infrared spectroscopy, X-ray diffraction analysis, scanning electron microscope, energy-dispersive X-ray spectroscopy, thermogravimetric analysis and differential thermal analysis techniques. The catalytic activity of this silica-supported lanthanum (III) chloride was investigated in a one-pot three-component Kabachnik-Fields reaction. A library of new α-aminophosphonates was prepared employing various benzothiazole and thiadiazole amines, different substituted aldehydes and diethylphosphite under solvent-free conditions using conventional/microwave methods with good to excellent yields (85–97%). The advantages of this catalyst are that it is environmentally benign, economically inexpensive, and easy to prepare, gives high yields and high purity is less time-consuming, offers easy purification is reusable and enables products to be obtained by simple recrystallization without column chromatography. Graphical Abstract
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-021-10360-x