Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial

Purpose The aim of this study was to evaluate the short- and long-term effects of the Fasting-Mimicking-Diet (FMD) intervention on neuromuscular parameters of force production in healthy young men. Methods Twenty-four physically active men completed the study. Participants were randomly assigned to...

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Bibliographic Details
Published in:European journal of applied physiology 2022-03, Vol.122 (3), p.651-661
Main Authors: Nardon, Mauro, Venturelli, Massimo, Ruzzante, Federico, Longo, Valter D., Bertucco, Matteo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomedical and Life Sciences
Biomedicine
Body mass
Body Mass Index
Diet
Electromyography
Fasting
Human Physiology
Humans
Isometric Contraction - physiology
Leg - physiology
Long-term effects
Male
Mimicry
Muscle contraction
Muscle, Skeletal - physiology
Occupational Medicine/Industrial Medicine
Original Article
Sarcopenia
Skeletal muscle
Sports Medicine
Torque
Young adults
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Summary:Purpose The aim of this study was to evaluate the short- and long-term effects of the Fasting-Mimicking-Diet (FMD) intervention on neuromuscular parameters of force production in healthy young men. Methods Twenty-four physically active men completed the study. Participants were randomly assigned to Fasting-Mimicking (FMD) or Normal Diet (ND) and asked to follow three cycles of dietary intervention. Neuromuscular parameters of force production during maximal voluntary isometric contractions (MVCs) with the leg extensors muscles and anthropometrics were measured at baseline (T0), at the end of the first cycle (T1), and 7–10 days after the 3rd cycle of the nutritional intervention (T2). The study was registered on Clinicaltrials.gov (No. NCT04476615). Results There was a significant decrease in body mass at T1 for FMD (− 2.6 kg, ∆ from baseline, on average; p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-021-04867-2