Proteolysis of Orai1 controls cellular Ca2+ influx

•Cellular Ca2+ signaling is fine-tuned by a set of Ca2+ sensitive protein to control a variety of biological functions.•The rhomboid intramembrane protease RHBDL2 can downregulate abnormal Ca2+ entry via CRAC channels.•RHBDL2 is sensitive to elevations in intracellular Ca2+ concentrations and the pr...

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2022-03, Vol.102, p.102535-102535, Article 102535
Main Author: Derler, Isabella
Format: Article
Language:English
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Summary:•Cellular Ca2+ signaling is fine-tuned by a set of Ca2+ sensitive protein to control a variety of biological functions.•The rhomboid intramembrane protease RHBDL2 can downregulate abnormal Ca2+ entry via CRAC channels.•RHBDL2 is sensitive to elevations in intracellular Ca2+ concentrations and the presence of a proline in the TM domain containing the rhomboid cleavage site.•The gain-of-function mutant Orai1 P245L linked to the stormorken syndrome is defective in RHBDL2 mediated cleavage. [Display omitted]
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2022.102535