The role of T-LAK cell-originated protein kinase in targeted cancer therapy

Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exce...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2022-03, Vol.477 (3), p.759-769
Main Authors: Zhang, Lu, Wang, Fei, Yi, Huijun, Ermakova, Svetlana P., Malyarenko, Olesya S., Mo, Jianmei, Huang, Yingze, Duan, Qiuhong, Xiao, Juanjuan, Zhu, Feng
Format: Article
Language:English
Subjects:
Animals
Antimitotic agents
Antineoplastic agents
Apoptosis
Apoptosis - drug effects
Biochemistry
Biomedical and Life Sciences
Cancer
Cancer therapies
Cardiology
Care and treatment
Cell migration
Cell proliferation
Cell Proliferation - drug effects
Development and progression
Drug Delivery Systems
Drug resistance
Fetuses
Germ cells
Health aspects
Humans
Killer cells
Kinases
Life Sciences
MAP kinase
Medical Biochemistry
Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinase Kinases - metabolism
Neoplasm Proteins - antagonists & inhibitors
Neoplasm Proteins - metabolism
Neoplasms - drug therapy
Neoplasms - enzymology
Oncology
Pantoprazole
Protein kinase
Protein Kinase Inhibitors - therapeutic use
Protein kinases
Proteins
Side effects
Signal Transduction - drug effects
Targeted cancer therapy
Therapeutic targets
Therapy
Tumors
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Summary:Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK cell-originated protein kinase), a MAP kinase, is highly expressed in various tumor tissues, while it is rarely expressed in normal tissues, with the exceptions of testicular germ cells and some fetal tissues. It can promote cancer cell proliferation and migration and is also related to drug resistance. Therefore, TOPK is considered a good therapeutic target. Moreover, a number of studies have shown that targeting TOPK can inhibit the proliferation of cancer cells and promote their apoptosis. Here, we discussed the biological functions of TOPK in cancer and summarized its tumor-related signaling network and known TOPK inhibitors. Finally, the role of TOPK in targeted cancer therapy was concluded, and future research directions for TOPK were assessed.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-021-04329-5