Frailty influences the vascular responsiveness of elderly individuals with chronic heart failure

• Published in: Microvascular research 2022-05, Vol.141, p.104316-104316, Article 104316
• Main Authors: Rech, Daiana Aparecida, Silveira, Lucas Santos da, Martins, Edgar Manoel, Roque, Ana Beatriz Alves de Oliveira, Althoff, Amanda, Maiorana, Andrew John, Vieira, Ariany Marques, Karsten, Marlus
• Format: Article
• Language: English
• Subjects: Aged; Chronic Disease; Exercise; Female; Frailty; Frailty - complications; Frailty - diagnosis; Hand Strength; Heart failure; Heart Failure - diagnosis; Humans; Male; Oxygen; Oxygen Consumption; Spectroscopy, Near-Infrared; Vascular responsiveness
• ISSN: 0026-2862; 1095-9319
• DOI: 10.1016/j.mvr.2022.104316

Frailty is highly prevalent in heart failure (HF) patients. HF is associated with oxidative stress and chronic inflammation, which impair oxygen use by skeletal muscles. Little is known about the influence of frailty on vascular responsiveness and tissue oxygenation. Analyze the influence of frailty on vascular responsiveness and muscle oxygenation in elderly individuals with and without HF. Individuals aged ≥60 years, with or without HF, were evaluated for frailty (phenotype). Near-infrared spectroscopy (NIRS) was used to assess muscle oxygenation at rest (oxygen saturation – StO2 and deoxyhemoglobin) and during handgrip exercise (minimum StO2 and maximum deoxyhemoglobin), and oxygenation variables. Results were grouped according to the frailty phenotype: non-frail, pre-frail, and frail. Shapiro-Wilk test was used to assess normality. Data were compared using a two-way analysis of variance (ANOVA). Bonferroni post hoc test was applied to determine the influence of frailty or HF on NIRS variables. SPSS software was used in the analyses; p