Potential therapeutic effects of avenanthramide-C against lung toxicity caused by silver nanoparticles injection in rats

Most clinical investigations about the impact of nanoparticles on cells and tissues show that nanoparticles may enter the human body by means of respiratory tracts. Humans, animals, plants and environments are continually presented to a wide scope of business items containing silver nanoparticles (A...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-01, Vol.34 (1(Supplementary)), p.337-343
Main Authors: Altwaijry, Najla, El-Masry, Thanaa A, Alotaibi, Badriyah S, Tousson, Ehab, Alodhayani, Abdulaziz A, El-Morshedy, Kadreya, Elmaghed, Nouf A, Sayed, Ahmed E, Saleh, Asmaa
Format: Article
Language:English
Subjects:
Animals
Blood Cells - drug effects
Cyclooxygenase 2 - drug effects
Cyclooxygenase 2 - metabolism
Erythrocyte Count
Hematocrit
Hemoglobins - drug effects
Hemoglobins - metabolism
Leukocyte Count
Lung - drug effects
Lung - pathology
Lung Injury - chemically induced
Lung Injury - pathology
Metal Nanoparticles - adverse effects
ortho-Aminobenzoates - pharmacology
Platelet Count
Rats
Silver - adverse effects
Tumor Necrosis Factor-alpha - drug effects
Tumor Necrosis Factor-alpha - metabolism
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Summary:Most clinical investigations about the impact of nanoparticles on cells and tissues show that nanoparticles may enter the human body by means of respiratory tracts. Humans, animals, plants and environments are continually presented to a wide scope of business items containing silver nanoparticles (Ag NPs) in their piece. Ag NPs, utilized in various consumer products as room showers, surface cleaners, wound dressings, food storage containers and many textiles. The current examination planned to explore the defensive role of Avenanthramide-C (Avns) contrary to the lung toxicity initiated by Ag NPs injection in rats. 40 male Wistar rats were separated into 4 groups (Gp1, control; Gp2, Avns; Gp3, Ag NPs; Gp4, Ag NPs+Avns). Current results revealed that; Ag NPs induced a significant depletion in RBCs count, hemoglobin, platelets counts and a significant increase in total WBCs, lung injury, cyclooxygenase-2 (COX2) and TNFα expressions as compared to control. Treatments of Ag NPs with Avenanthramide-C extract (Ag NPs+Avns) improved the lung structure and blood complete pictures as compared to Ag NPs group.
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.1.SUP.337-343.1