Activity guided isolation and mechanistic approach towards analgesic potential of Chenopodium mediated through opioidergic pathway

The current study is focused towards screening for its phytochemicals, phenolic and flavonoid contents of different species of Chenopodium. The plants were also screened for corroborating the traditional use of medicinal plants locally used for pain by determining the extract and their fractions for...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-01, Vol.34 (1(Supplementary)), p.197-203
Main Authors: Nasim, Sahar, Shah, Mohib, Ali Shah, Syed Wadood, Ahmed, Muhammad Naeem, Ahmad, Mubashir, Anwar, Natasha, Ghias, Mehreen
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Behavior, Animal - drug effects
Chenopodium
Chenopodium album
Chenopodium ambrosioides
Drug Discovery
Flavonoids
Mice
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
Phenols - pharmacology
Phytochemicals - pharmacology
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Sitosterols - pharmacology
Triterpenes - pharmacology
Ursolic Acid
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Summary:The current study is focused towards screening for its phytochemicals, phenolic and flavonoid contents of different species of Chenopodium. The plants were also screened for corroborating the traditional use of medicinal plants locally used for pain by determining the extract and their fractions for the in-vivo analgesic activity by using the modern scientific system. Among chloroform fractions, a high level of total phenolic contents was found in chloroform fraction of Chenopodium ambrosioides (ChAm-Chf) with 57.12±1.02 followed by Chenopodium botrys (ChBt-Chf) with 56.79±0.71. High content of flavonoids was found in chloroform fraction of Chenopodium botrys (ChBt-Chf) extract with 78.35±0.84 followed by Chenopodium ambrosioides (ChAm-Chf) with 75.20±0.81. The crude extract Chenopodium album, Chenopodium botrys and Chenopodium ambrosioides (ChAl-Crd, ChBt-Crd and ChAm-Crd) at 100 and 200 mg/kg, chloroform and ethylacetate fractions (ChAl-Chf, ChBt-Chf, ChAm-Chf, ChAl-Et, ChBt-Et and ChAm-Et) at 75 mg/kg caused significant inhibition (P
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.1.SUP.197-203.1