Rosettes: a shield for Plasmodium falciparum against artemisinins?

Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. D...

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Bibliographic Details
Published in:Trends in parasitology 2022-03, Vol.38 (3), p.193-194
Main Author: Rogerson, Stephen J.
Format: Article
Language:English
Subjects:
Antimalarials - pharmacology
Antimalarials - therapeutic use
Artemisinins - pharmacology
Artesunate
drug resistance
Erythrocytes - parasitology
malaria
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
rosetting
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Summary:Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2021.12.009