Pharmacogenetic differentiation across Latin America

To explore the pharmacogenetic differentiation across Latin American populations, using the fixation index statistics (F ). F analyses were applied to 1519 pharmacogenetic markers in the 1000 Genomes admixed American superpopulation (1KG_AMR) and an admixed Brazilian sample. Allele-specific F values...

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Bibliographic Details
Published in:Pharmacogenomics 2022-03, Vol.23 (4), p.225-233
Main Authors: Suarez-Kurtz, Guilherme, de Araújo, Gilderlanio Santana
Format: Article
Language:English
Subjects:
biogeographical ancestry
fixation index statistics
Genetics, Population
Humans
Latin America
Latin American population
pharmacogenetic differentiation
population admixture
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Summary:To explore the pharmacogenetic differentiation across Latin American populations, using the fixation index statistics (F ). F analyses were applied to 1519 pharmacogenetic markers in the 1000 Genomes admixed American superpopulation (1KG_AMR) and an admixed Brazilian sample. Allele-specific F values for the overall cohort point to little overall pharmacogenetic differentiation (average F  = 0.017); however, moderate differentiation (F  = 0.05–0.15) was observed for 83 markers, while large differentiation (F  = 0.15–0.25) was restricted to three markers. Pairwise F analysis identified three markers with very large differentiation (F  >0.25). The present study verifies and extends previous reports of little overall pharmacogenetic divergence across Latin America, although a number of markers display substantial differentiation.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2021-0152