Maternal hyperandrogenism is associated with a higher risk of type 2 diabetes mellitus and overweight in adolescent and adult female offspring: a long-term population-based follow-up study

Purpose Adverse intrauterine environment may predispose offspring to cardio-metabolic dysfunction in later life. In this study, we aimed to investigate the effects of maternal hyperandrogenism (MH) on cardio-metabolic risk factors in female offspring in later life. Methods This prospective populatio...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2022-05, Vol.45 (5), p.963-972
Main Authors: Noroozzadeh, M., Rahmati, M., Behboudi-Gandevani, S., Ramezani Tehrani, F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Birth weight
Body Mass Index
Body weight
Child
Children
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diabetes, Gestational - epidemiology
Endocrinology
Female
Females
Follow-Up Studies
Humans
Hyperandrogenism - epidemiology
Hyperandrogenism - etiology
Internal Medicine
Intrauterine exposure
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Obesity
Offspring
Original Article
Overweight
Overweight - complications
Overweight - epidemiology
Pediatric Obesity
Physical activity
Population studies
Population-based studies
Prediabetic State
Pregnancy
Prospective Studies
Regression analysis
Risk Factors
Statistical analysis
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Summary:Purpose Adverse intrauterine environment may predispose offspring to cardio-metabolic dysfunction in later life. In this study, we aimed to investigate the effects of maternal hyperandrogenism (MH) on cardio-metabolic risk factors in female offspring in later life. Methods This prospective population-based study included 211 female offspring with MH and 757 female offspring without MH (controls). Both groups were followed from baseline to the date of incidence of events, censoring, or end of the study period, whichever came first. Age scaled unadjusted and adjusted cox regression models were applied to assess the hazard ratios (HR) and 95% confidence intervals (CIs) for the association of MH with pre-diabetes (pre-DM), type 2 diabetes mellitus (T2DM), overweight and obesity in offspring of both groups. Statistical analysis was performed using the software package STATA; significance level was set at P  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-021-01721-2