A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004–20 in Spain

Abstract Background Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains. Objectives To determine the susceptibility o...

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Published in:Journal of antimicrobial chemotherapy 2022-03, Vol.77 (4), p.1045-1051
Main Authors: Sempere, Julio, González-Camacho, Fernando, Domenech, Mirian, Llamosí, Mirella, Del Río, Idoia, López-Ruiz, Beatriz, Gimeno, Mercedes, Coronel, Pilar, Yuste, Jose
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Cephalosporins - pharmacology
Humans
Longitudinal Studies
Microbial Sensitivity Tests
Pneumococcal Infections - epidemiology
Spain - epidemiology
Streptococcus pneumoniae
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Summary:Abstract Background Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility of commonly used antibiotics and the contribution of conjugate vaccines against resistant strains. Objectives To determine the susceptibility of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to penicillin to a panel of antibiotics during the period 2004–20 and characterize the impact of pneumococcal conjugate vaccines in the evolution of resistant serotypes. Methods We selected 3017 clinical isolates in order to determine the minimal inhibitory concentration to penicillin, amoxicillin, cefotaxime, erythromycin, levofloxacin and oral cephalosporins, including cefditoren, cefixime and cefpodoxime. Results The antibiotics with the lowest proportion of resistant strains from 2004 to 2020 were cefditoren (
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkab482