Serum kisspeptin levels along reproductive period in women: is it a marker for aging?

To demonstrate the change in serum kisspeptin levels during the reproductive period in healthy women and to investigate the relationship with other reproductive hormones. One hundred thirty-one healthy women with normal menstrual history were included and serum kisspeptin, follicle-stimulating hormo...

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Bibliographic Details
Published in:Gynecological endocrinology 2022-03, Vol.38 (3), p.267-272
Main Authors: Erel, C. Tamer, Ozcivit, Ipek Betul, Inan, Deniz, Mut, Aysegül, Karakus Hatipoglu, Burçin, Konukoglu, Dildar
Format: Article
Language:English
Subjects:
Adult
age
Aging
Anti-Mullerian Hormone
Estradiol
Female
Follicle Stimulating Hormone
Humans
Kisspeptin
Kisspeptins
Luteinizing Hormone
menopause
Reproduction
Young Adult
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Summary:To demonstrate the change in serum kisspeptin levels during the reproductive period in healthy women and to investigate the relationship with other reproductive hormones. One hundred thirty-one healthy women with normal menstrual history were included and serum kisspeptin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), estradiol (E 2 ), and anti-Müllerian hormone (AMH) levels were determined on cycle day 3. The data were analyzed in 5-year age groups. Serum kisspeptin levels of all women were found to be significantly and negatively correlated with age (r= −0.458). The kisspeptin levels were the highest in the group of women aged between 20 and 24 years compared to other age groups above 25 years (p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2022.2028768