The Primary Motor Cortex: The Hub of Motor Learning in Rodents

•The primary motor cortex receives diverse inputs in a laminar-specific manner.•The primary motor cortex undergoes extensive synaptic plasticity upon motor learning.•Immediate early gene c-fos and Arc is closely associated with the primary motor cortex. The primary motor cortex, a dynamic center for...

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Bibliographic Details
Published in:Neuroscience 2022-03, Vol.485, p.163-170
Main Authors: Lee, Chaery, Kim, Yeonjun, Kaang, Bong-Kiun
Format: Article
Language:English
Subjects:
Animals
Dendritic Spines - physiology
motor cortex
Motor Cortex - physiology
motor learning
neuronal circuit
Neuronal Plasticity - physiology
rodent
Rodentia
Synapses - physiology
synaptic plasticity
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Summary:•The primary motor cortex receives diverse inputs in a laminar-specific manner.•The primary motor cortex undergoes extensive synaptic plasticity upon motor learning.•Immediate early gene c-fos and Arc is closely associated with the primary motor cortex. The primary motor cortex, a dynamic center for overall motion control and decision making, undergoes significant alterations upon neural stimulation. Over the last few decades, data from numerous studies using rodent models have improved our understanding of the morphological and functional plasticity of the primary motor cortex. In particular, spatially specific formation of dendritic spines and their maintenance during distinct behaviors is considered crucial for motor learning. However, whether the modifications of specific synapses are associated with motor learning should be studied further. In this review, we summarized the findings of prior studies on the features and dynamics of the primary motor cortex in rodents.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2022.01.009