Role of interleukin-17 signaling pathway in the interaction between multiple sclerosis and acute myocardial infarction

• Published in: Multiple sclerosis and related disorders 2022-02, Vol.58, p.103515-103515, Article 103515
• Main Author: Jain, Shivam
• Format: Article
• Language: English
• Subjects: Acute myocardial infarction; Computational Biology - methods; Gene expression profiling; Gene Expression Profiling - methods; Humans; IL-17 signaling pathway; Interleukin-17 - genetics; Multiple sclerosis; Multiple Sclerosis - genetics; Myocardial Infarction - genetics; Signal Transduction - genetics
• ISSN: 2211-0348; 2211-0356
• DOI: 10.1016/j.msard.2022.103515

•The MS-AMI relationship has a genetic underlying mechanism.•The IL-17 signaling pathway plays a role in increased AMI incidence in MS patients.•Anti-microbial genes and cytokines are involved in the MS-AMI relationship.•Prion diseases and Graft-versus-host diseases could play a role in MS and/or AMI. A correlational relationship has been well established between Multiple Sclerosis and Acute Myocardial Infarction incidence. However, the etiology underlying this relationship remains unclear. The purpose of this study is to investigate the mechanisms behind the relationship by identifying candidate genes in the interaction between the two diseases. Using a computational biology approach and existing gene expression data from the NIH Gene Expression Omnibus, meta-analysis was conducted on six datasets to evaluate upregulated or downregulated genes shared between both diseases. Overlapping genes were then evaluated in STRING to find a KEGG biological pathway connecting these genes. Meta-analysis found 78 overlap genes for upregulation and 65 for downregulation. These genes displayed significant interaction in the STRING network. The most plausible KEGG pathway resulting from the STRING analysis was the Interleukin-17 Signaling Pathway. Seven of the genes from the meta-analysis (S100A8, S100A9, CXCL8, COX2, AP-1, IKBA, and A20) are involved in this pathway. The IL-17 signaling pathway influences the relationship between Multiple Sclerosis and Acute Myocardial Infarction and represents a potential target for drug intervention.