Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii

Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A–I (1–9), were discovered from the fungus Eupen...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2022-02, Vol.85 (2), p.384-390
Main Authors: Morishita, Yohei, Tsukada, Kento, Murakami, Kazuma, Irie, Kazuhiro, Asai, Teigo
Format: Article
Language:English
Subjects:
Diterpenes - metabolism
Diterpenes - pharmacology
Penicillium
Pyrones - pharmacology
Synthetic Biology
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Summary:Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A–I (1–9), were discovered from the fungus Eupenicillium shearii IFM 42152, and their biosynthetic enzyme activities were revealed. Some of these heterologously biosynthesized diterpenoid pyrones exhibited moderate antiaggregative ability against amyloid β42 in vitro.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.1c00973