Serum levels of lipocalin-2 are elevated at early times in African American relapsing remitting multiple sclerosis patients

Previous studies showed that depleting Liver Kinase-B1 (LKB1) from astrocytes increased inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide polymorphism (SNP) in STK11 (encoding LKB1) is a risk factor for MS, suggesting increased LCN2 or OPN contributes to risk....

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Published in:Journal of neuroimmunology 2022-03, Vol.364, p.577810-577810, Article 577810
Main Authors: Kalinin, Sergey, Boullerne, Anne I., Feinstein, Douglas L.
Format: Article
Language:English
Subjects:
Adult
African Americans - genetics
AMP-Activated Protein Kinase Kinases - genetics
Biomarker
Biomarkers - blood
Disease Progression
Female
Genetic Predisposition to Disease - genetics
Humans
LCN2
Lipocalin-2
Lipocalin-2 - blood
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - blood
Multiple Sclerosis, Relapsing-Remitting - genetics
Osteopontin
Osteopontin - blood
Polymorphism, Single Nucleotide
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Summary:Previous studies showed that depleting Liver Kinase-B1 (LKB1) from astrocytes increased inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide polymorphism (SNP) in STK11 (encoding LKB1) is a risk factor for MS, suggesting increased LCN2 or OPN contributes to risk. Serum LCN2 and OPN levels in African American female MS patients were higher than healthy controls, and while levels increased with disease duration in cases without the SNP, levels decreased with duration in cases with the SNP. Increased MS risk associated with the STK11 SNP may be due to higher LCN2 or OPN levels at early times. •A SNP in the gene STK11 which codes for LKB1 is a risk factor for MS in women.•LKB1 deficiency increases inflammatory proteins including LCN-2 and OPN.•LCN2 and OPN levels are higher in African American female MS patients with the SNP.•Higher levels were seen after short, but not long, disease duration times.•Elevated LCN2/OPN levels may contribute to increased MS risk due to the STK11 SNP.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2022.577810