Clinical and radiologic spectrum of glandular odontogenic cysts: A multicenter study of 92 cases

The purpose of this multicenter retrospective study was to report the clinical and radiologic features of 92 glandular odontogenic cysts (GOCs) diagnosed over a 20-year period. Histologically confirmed cases of GOC were retrospectively reviewed from 4 oral pathology laboratories in South Africa and...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2022-05, Vol.133 (5), p.593-603
Main Authors: Nel, Chané, Robinson, Liam, Roza, Ana Luiza Oliveira Corrêa, Ker-Fox, Jason, Gomes, Nathália Rodrigues, Fonseca, Felipe Paiva, Santos-Silva, Alan Roger, Romañach, Mário José, Vargas, Pablo Agustin, van Heerden, Willie FP
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Brazil
Female
Humans
Male
Mandible - pathology
Mandibular Diseases - pathology
Maxilla - pathology
Middle Aged
Odontogenic Cysts - diagnostic imaging
Odontogenic Cysts - pathology
Retrospective Studies
Young Adult
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Summary:The purpose of this multicenter retrospective study was to report the clinical and radiologic features of 92 glandular odontogenic cysts (GOCs) diagnosed over a 20-year period. Histologically confirmed cases of GOC were retrospectively reviewed from 4 oral pathology laboratories in South Africa and Brazil to categorize the clinical and radiologic spectrum of GOCs. The mean age of patients was 46 years (range 17-87) with a male-to-female ratio of 1.2:1. GOCs had a mandibular predilection (68%), with 42% of all cases located anteriorly. Additionally, 42% of cases crossed the midline. Radiologically, most lesions were unilocular (53%) and uniformly radiolucent (97%), with well-demarcated borders (93%). Cortical expansion (62%), loss of cortical integrity (71%), and maxillary sinus (67%) and nasal cavity encroachment (72%) were common findings. Significant differences in lesions between the 2 countries were discovered in sex predilection, clinical signs and symptoms, and lesion locations within the mandible and maxilla. GOCs present with a wide spectrum of clinical and radiologic features, ranging from cysts with typical GOC-like presentations to more aggressive lesions. The need for advanced imaging in the surgical planning of GOCs exhibiting radiologic signs of aggression is justified based on the high recurrence rate.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2021.11.008