Loading…
Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification
Objectives To compare all‐cause mortality in patients with mitral annulus calcification (MAC) and severe mitral valve dysfunction (MVD) who received standard mitral intervention versus no intervention. Background Patients with MAC often have high surgical risk due to advanced age, comorbidities, and...
Saved in:
| Published in: | Catheterization and cardiovascular interventions 2022-05, Vol.99 (6), p.1807-1816 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33 |
| container_end_page | 1816 |
| container_issue | 6 |
| container_start_page | 1807 |
| container_title | Catheterization and cardiovascular interventions |
| container_volume | 99 |
| creator | Kato, Nahoko Pellikka, Patricia A. Scott, Christopher G. Lee, Alexander T. Jain, Vaibhav Eleid, Mackram F. Alkhouli, Mohamad A. Reeder, Guy S. Michelena, Hector I. Pislaru, Sorin V. Bagameri, Gabor Crestanello, Juan A. Rihal, Charanjit S. Guerrero, Mayra |
| description | Objectives
To compare all‐cause mortality in patients with mitral annulus calcification (MAC) and severe mitral valve dysfunction (MVD) who received standard mitral intervention versus no intervention.
Background
Patients with MAC often have high surgical risk due to advanced age, comorbidities, and technical challenges related to calcium. The impact of a mitral intervention on outcomes of patients with MAC and severe MVD is not well known.
Methods
Retrospective review of patients with MAC by transthoracic echocardiography (TTE) in 2015 at a single institution. Patients with severe mitral stenosis (MS) or regurgitation (MR) were analyzed and stratified into two groups: surgical or transcatheter intervention performed |
| doi_str_mv | 10.1002/ccd.30093 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2622480581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622480581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33</originalsourceid><addsrcrecordid>eNp10ctKAzEUBuAgiq3VhS8gA250MW3uM7OUeisU3Ci4G9KTBFPmUiczLX17007rQhASEjjf-Qk5CF0TPCYY0wmAHjOMM3aChkRQGidUfp4e7iTjcoAuvF_iQCTNztGACSxllqZDVM7KlYI2qm1UurZRReSq1jRrU7WurqLd6lqoS-N3ZKVaFyo-2rj269iwVsXaRHrrbVfBvktVOuyqKzofgSrAWQdqV7lEZ1YV3lwdzhH6eH56n77G87eX2fRhHgMTjMVcGKmtZalJzQJAkpRbLSzXjCWgaGItpSxVkHGxEFlGCNci4xiISjRIy9gI3fW5q6b-7oxv89J5MEWhKlN3PqeSUp5ikZJAb__QZd01VXhdUJJTRjhOgrrvFTS1942x-apxpWq2OcH5bgZ5mEG-n0GwN4fEblEa_SuPnx7ApAcbV5jt_0n5dPrYR_4ANXaRtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2664231407</pqid></control><display><type>article</type><title>Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Kato, Nahoko ; Pellikka, Patricia A. ; Scott, Christopher G. ; Lee, Alexander T. ; Jain, Vaibhav ; Eleid, Mackram F. ; Alkhouli, Mohamad A. ; Reeder, Guy S. ; Michelena, Hector I. ; Pislaru, Sorin V. ; Bagameri, Gabor ; Crestanello, Juan A. ; Rihal, Charanjit S. ; Guerrero, Mayra</creator><creatorcontrib>Kato, Nahoko ; Pellikka, Patricia A. ; Scott, Christopher G. ; Lee, Alexander T. ; Jain, Vaibhav ; Eleid, Mackram F. ; Alkhouli, Mohamad A. ; Reeder, Guy S. ; Michelena, Hector I. ; Pislaru, Sorin V. ; Bagameri, Gabor ; Crestanello, Juan A. ; Rihal, Charanjit S. ; Guerrero, Mayra</creatorcontrib><description>Objectives
To compare all‐cause mortality in patients with mitral annulus calcification (MAC) and severe mitral valve dysfunction (MVD) who received standard mitral intervention versus no intervention.
Background
Patients with MAC often have high surgical risk due to advanced age, comorbidities, and technical challenges related to calcium. The impact of a mitral intervention on outcomes of patients with MAC and severe MVD is not well known.
Methods
Retrospective review of patients with MAC by transthoracic echocardiography (TTE) in 2015 at a single institution. Patients with severe mitral stenosis (MS) or regurgitation (MR) were analyzed and stratified into two groups: surgical or transcatheter intervention performed <1 year after the index TTE, and no or later intervention. The primary endpoint was all‐cause mortality.
Results
Of 5502 patients with MAC, 357 had severe MVD (MS = 27%, MR = 73%). Of those, 108 underwent mitral intervention (surgery = 87; transcatheter = 21). They were younger (73 ± 11 vs. 76 ± 11 years, p < 0.01) and less frequently had cardiovascular diseases compared with no‐intervention. Frequency in women was similar (45% vs. 50%, p = 0.44). During median follow‐up of 3.2 years, the intervention group had higher estimated survival than those without intervention (80% vs. 72% at 1 year and 55% vs. 35% at 4 year, p < 0.01). Adjusted for age, eGFR, LVEF < 50%, and pulmonary hypertension, mitral intervention was an independent predictor of lower mortality (hazard ratio = 0.66, 95% confidence interval 0.43–0.99, p = 0.046).
Conclusion
Patients with MAC and severe MVD who underwent mitral intervention <1 year from index TTE had lower mortality than those without intervention. Mitral intervention was independently associated with lower mortality.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.30093</identifier><identifier>PMID: 35066988</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Calcification ; Calcification (ectopic) ; Cardiovascular diseases ; Echocardiography ; mitral annulus calcification ; mitral regurgitation ; mitral repair ; mitral replacement ; mitral stenosis ; Mitral valve ; Mortality ; Patients ; Regurgitation ; Stenosis ; transcatheter mitral intervention</subject><ispartof>Catheterization and cardiovascular interventions, 2022-05, Vol.99 (6), p.1807-1816</ispartof><rights>2022 Wiley Periodicals LLC</rights><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33</citedby><cites>FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33</cites><orcidid>0000-0001-6800-3521 ; 0000-0001-6082-5379 ; 0000-0002-9151-8096 ; 0000-0003-0892-4366</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35066988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kato, Nahoko</creatorcontrib><creatorcontrib>Pellikka, Patricia A.</creatorcontrib><creatorcontrib>Scott, Christopher G.</creatorcontrib><creatorcontrib>Lee, Alexander T.</creatorcontrib><creatorcontrib>Jain, Vaibhav</creatorcontrib><creatorcontrib>Eleid, Mackram F.</creatorcontrib><creatorcontrib>Alkhouli, Mohamad A.</creatorcontrib><creatorcontrib>Reeder, Guy S.</creatorcontrib><creatorcontrib>Michelena, Hector I.</creatorcontrib><creatorcontrib>Pislaru, Sorin V.</creatorcontrib><creatorcontrib>Bagameri, Gabor</creatorcontrib><creatorcontrib>Crestanello, Juan A.</creatorcontrib><creatorcontrib>Rihal, Charanjit S.</creatorcontrib><creatorcontrib>Guerrero, Mayra</creatorcontrib><title>Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification</title><title>Catheterization and cardiovascular interventions</title><addtitle>Catheter Cardiovasc Interv</addtitle><description>Objectives
To compare all‐cause mortality in patients with mitral annulus calcification (MAC) and severe mitral valve dysfunction (MVD) who received standard mitral intervention versus no intervention.
Background
Patients with MAC often have high surgical risk due to advanced age, comorbidities, and technical challenges related to calcium. The impact of a mitral intervention on outcomes of patients with MAC and severe MVD is not well known.
Methods
Retrospective review of patients with MAC by transthoracic echocardiography (TTE) in 2015 at a single institution. Patients with severe mitral stenosis (MS) or regurgitation (MR) were analyzed and stratified into two groups: surgical or transcatheter intervention performed <1 year after the index TTE, and no or later intervention. The primary endpoint was all‐cause mortality.
Results
Of 5502 patients with MAC, 357 had severe MVD (MS = 27%, MR = 73%). Of those, 108 underwent mitral intervention (surgery = 87; transcatheter = 21). They were younger (73 ± 11 vs. 76 ± 11 years, p < 0.01) and less frequently had cardiovascular diseases compared with no‐intervention. Frequency in women was similar (45% vs. 50%, p = 0.44). During median follow‐up of 3.2 years, the intervention group had higher estimated survival than those without intervention (80% vs. 72% at 1 year and 55% vs. 35% at 4 year, p < 0.01). Adjusted for age, eGFR, LVEF < 50%, and pulmonary hypertension, mitral intervention was an independent predictor of lower mortality (hazard ratio = 0.66, 95% confidence interval 0.43–0.99, p = 0.046).
Conclusion
Patients with MAC and severe MVD who underwent mitral intervention <1 year from index TTE had lower mortality than those without intervention. Mitral intervention was independently associated with lower mortality.</description><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiovascular diseases</subject><subject>Echocardiography</subject><subject>mitral annulus calcification</subject><subject>mitral regurgitation</subject><subject>mitral repair</subject><subject>mitral replacement</subject><subject>mitral stenosis</subject><subject>Mitral valve</subject><subject>Mortality</subject><subject>Patients</subject><subject>Regurgitation</subject><subject>Stenosis</subject><subject>transcatheter mitral intervention</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp10ctKAzEUBuAgiq3VhS8gA250MW3uM7OUeisU3Ci4G9KTBFPmUiczLX17007rQhASEjjf-Qk5CF0TPCYY0wmAHjOMM3aChkRQGidUfp4e7iTjcoAuvF_iQCTNztGACSxllqZDVM7KlYI2qm1UurZRReSq1jRrU7WurqLd6lqoS-N3ZKVaFyo-2rj269iwVsXaRHrrbVfBvktVOuyqKzofgSrAWQdqV7lEZ1YV3lwdzhH6eH56n77G87eX2fRhHgMTjMVcGKmtZalJzQJAkpRbLSzXjCWgaGItpSxVkHGxEFlGCNci4xiISjRIy9gI3fW5q6b-7oxv89J5MEWhKlN3PqeSUp5ikZJAb__QZd01VXhdUJJTRjhOgrrvFTS1942x-apxpWq2OcH5bgZ5mEG-n0GwN4fEblEa_SuPnx7ApAcbV5jt_0n5dPrYR_4ANXaRtg</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Kato, Nahoko</creator><creator>Pellikka, Patricia A.</creator><creator>Scott, Christopher G.</creator><creator>Lee, Alexander T.</creator><creator>Jain, Vaibhav</creator><creator>Eleid, Mackram F.</creator><creator>Alkhouli, Mohamad A.</creator><creator>Reeder, Guy S.</creator><creator>Michelena, Hector I.</creator><creator>Pislaru, Sorin V.</creator><creator>Bagameri, Gabor</creator><creator>Crestanello, Juan A.</creator><creator>Rihal, Charanjit S.</creator><creator>Guerrero, Mayra</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6800-3521</orcidid><orcidid>https://orcid.org/0000-0001-6082-5379</orcidid><orcidid>https://orcid.org/0000-0002-9151-8096</orcidid><orcidid>https://orcid.org/0000-0003-0892-4366</orcidid></search><sort><creationdate>20220501</creationdate><title>Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification</title><author>Kato, Nahoko ; Pellikka, Patricia A. ; Scott, Christopher G. ; Lee, Alexander T. ; Jain, Vaibhav ; Eleid, Mackram F. ; Alkhouli, Mohamad A. ; Reeder, Guy S. ; Michelena, Hector I. ; Pislaru, Sorin V. ; Bagameri, Gabor ; Crestanello, Juan A. ; Rihal, Charanjit S. ; Guerrero, Mayra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Cardiovascular diseases</topic><topic>Echocardiography</topic><topic>mitral annulus calcification</topic><topic>mitral regurgitation</topic><topic>mitral repair</topic><topic>mitral replacement</topic><topic>mitral stenosis</topic><topic>Mitral valve</topic><topic>Mortality</topic><topic>Patients</topic><topic>Regurgitation</topic><topic>Stenosis</topic><topic>transcatheter mitral intervention</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kato, Nahoko</creatorcontrib><creatorcontrib>Pellikka, Patricia A.</creatorcontrib><creatorcontrib>Scott, Christopher G.</creatorcontrib><creatorcontrib>Lee, Alexander T.</creatorcontrib><creatorcontrib>Jain, Vaibhav</creatorcontrib><creatorcontrib>Eleid, Mackram F.</creatorcontrib><creatorcontrib>Alkhouli, Mohamad A.</creatorcontrib><creatorcontrib>Reeder, Guy S.</creatorcontrib><creatorcontrib>Michelena, Hector I.</creatorcontrib><creatorcontrib>Pislaru, Sorin V.</creatorcontrib><creatorcontrib>Bagameri, Gabor</creatorcontrib><creatorcontrib>Crestanello, Juan A.</creatorcontrib><creatorcontrib>Rihal, Charanjit S.</creatorcontrib><creatorcontrib>Guerrero, Mayra</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kato, Nahoko</au><au>Pellikka, Patricia A.</au><au>Scott, Christopher G.</au><au>Lee, Alexander T.</au><au>Jain, Vaibhav</au><au>Eleid, Mackram F.</au><au>Alkhouli, Mohamad A.</au><au>Reeder, Guy S.</au><au>Michelena, Hector I.</au><au>Pislaru, Sorin V.</au><au>Bagameri, Gabor</au><au>Crestanello, Juan A.</au><au>Rihal, Charanjit S.</au><au>Guerrero, Mayra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Catheter Cardiovasc Interv</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>99</volume><issue>6</issue><spage>1807</spage><epage>1816</epage><pages>1807-1816</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Objectives
To compare all‐cause mortality in patients with mitral annulus calcification (MAC) and severe mitral valve dysfunction (MVD) who received standard mitral intervention versus no intervention.
Background
Patients with MAC often have high surgical risk due to advanced age, comorbidities, and technical challenges related to calcium. The impact of a mitral intervention on outcomes of patients with MAC and severe MVD is not well known.
Methods
Retrospective review of patients with MAC by transthoracic echocardiography (TTE) in 2015 at a single institution. Patients with severe mitral stenosis (MS) or regurgitation (MR) were analyzed and stratified into two groups: surgical or transcatheter intervention performed <1 year after the index TTE, and no or later intervention. The primary endpoint was all‐cause mortality.
Results
Of 5502 patients with MAC, 357 had severe MVD (MS = 27%, MR = 73%). Of those, 108 underwent mitral intervention (surgery = 87; transcatheter = 21). They were younger (73 ± 11 vs. 76 ± 11 years, p < 0.01) and less frequently had cardiovascular diseases compared with no‐intervention. Frequency in women was similar (45% vs. 50%, p = 0.44). During median follow‐up of 3.2 years, the intervention group had higher estimated survival than those without intervention (80% vs. 72% at 1 year and 55% vs. 35% at 4 year, p < 0.01). Adjusted for age, eGFR, LVEF < 50%, and pulmonary hypertension, mitral intervention was an independent predictor of lower mortality (hazard ratio = 0.66, 95% confidence interval 0.43–0.99, p = 0.046).
Conclusion
Patients with MAC and severe MVD who underwent mitral intervention <1 year from index TTE had lower mortality than those without intervention. Mitral intervention was independently associated with lower mortality.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35066988</pmid><doi>10.1002/ccd.30093</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6800-3521</orcidid><orcidid>https://orcid.org/0000-0001-6082-5379</orcidid><orcidid>https://orcid.org/0000-0002-9151-8096</orcidid><orcidid>https://orcid.org/0000-0003-0892-4366</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1522-1946 |
| ispartof | Catheterization and cardiovascular interventions, 2022-05, Vol.99 (6), p.1807-1816 |
| issn | 1522-1946 1522-726X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2622480581 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Calcification Calcification (ectopic) Cardiovascular diseases Echocardiography mitral annulus calcification mitral regurgitation mitral repair mitral replacement mitral stenosis Mitral valve Mortality Patients Regurgitation Stenosis transcatheter mitral intervention |
| title | Impact of mitral intervention on outcomes of patients with mitral valve dysfunction and annulus calcification |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T07%3A49%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20mitral%20intervention%20on%20outcomes%20of%20patients%20with%20mitral%20valve%20dysfunction%20and%20annulus%20calcification&rft.jtitle=Catheterization%20and%20cardiovascular%20interventions&rft.au=Kato,%20Nahoko&rft.date=2022-05-01&rft.volume=99&rft.issue=6&rft.spage=1807&rft.epage=1816&rft.pages=1807-1816&rft.issn=1522-1946&rft.eissn=1522-726X&rft_id=info:doi/10.1002/ccd.30093&rft_dat=%3Cproquest_cross%3E2622480581%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3533-45e6dff38e8ebcc6184fd5f4d337ca27ff2238ac945b599114d5940c1a7dc6f33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2664231407&rft_id=info:pmid/35066988&rfr_iscdi=true |