Aspects of cognitive assessments and spectroscopic magnetic resonance imaging in people with chronic hepatitis C: a systematic review

Extrahepatic manifestations are common in people with hepatitis C virus (HCV). Cognitive changes are pointed out, but the mechanisms are still uncertain. The aim of this systematic review was to analyze studies involving spectroscopic magnetic resonance in people infected with HCV, which also includ...

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Published in:Psychology, health & medicine health & medicine, 2023-04, Vol.28 (4), p.1013-1029
Main Authors: Carvalho, Tatiana Lins, Mertens Brainer de Queiroz Lima, Alessandra Cintia, de Araújo, Noemi Salazar, de Sousa Fernandes, Matheus Santos, Lira, Gabriela Barza, de Melo, Marcela Maria Medeiros, Vasconcelos, Luydson Richardson Silva, de Moura, Patrícia Muniz Mendes Freire, da Cunha Correia, Carolina
Format: Article
Language:English
Subjects:
Brain - pathology
Cognition
Cognition Disorders
Cognitive change
cognitive dysfunction
Confounding factors
Fluency
Hepatitis C
hepatitis c chronic
Hepatitis C, Chronic - pathology
Humans
Information processing
Magnetic Resonance Imaging
magnetic resonance spectroscopy
Systematic review
Verbal memory
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Summary:Extrahepatic manifestations are common in people with hepatitis C virus (HCV). Cognitive changes are pointed out, but the mechanisms are still uncertain. The aim of this systematic review was to analyze studies involving spectroscopic magnetic resonance in people infected with HCV, which also included cognitive tests. The research occurred in six databases (Directory of Open Access Journals, Lilacs, Medcaribe, Medline, Scielo and ScienceDirect) and the selection of studies was carried out in two stages: search for titles and abstracts, then reading of the full articles, excluding those that did not meet the eligibility criteria. 12,888 titles and abstracts were selected, but only 6 articles were included in the review. Impairments in attention, concentration, speed of information processing, memory, verbal fluency and executive functions were identified as well as an increase in the Cho/Cr and mI/Cr ratios and a reduction in the NAA/Cr ratio in some included studies. Longitudinal studies, with more homogeneous samples and methods, as well as with better controlled confounding factors, are necessary to adequately identify the effect of HCV on the brain.
ISSN:1354-8506
1465-3966
DOI:10.1080/13548506.2022.2029915