Incorporating Fullerenes in Nanoscale Metal–Organic Matrixes: An Ultrasensitive Platform for Impedimetric Aptasensing of Tobramycin

The rational design and preparation of available fullerene@metal–organic matrix hybrid materials are of profound significance in electrochemical biosensing applications due to their unique photoelectric properties. In this work, C60@UiO-66-NH2 nanocomposites serve as greatly promising materials to m...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2022-02, Vol.14 (5), p.7350-7357
Main Authors: Zhang, Han-Wen, Li, Hong-Kai, Han, Zhang-Ye, Yuan, Rongrong, He, Hongming
Format: Article
Language:English
Subjects:
Amines - chemistry
Applications of Polymer, Composite, and Coating Materials
Aptamers, Nucleotide - chemistry
Biosensing Techniques - methods
Dielectric Spectroscopy
Fullerenes - chemistry
Humans
Metal-Organic Frameworks - chemistry
Nanocomposites - chemistry
Tobramycin - analysis
Tobramycin - blood
Tobramycin - urine
Zirconium - chemistry
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Summary:The rational design and preparation of available fullerene@metal–organic matrix hybrid materials are of profound significance in electrochemical biosensing applications due to their unique photoelectric properties. In this work, C60@UiO-66-NH2 nanocomposites serve as greatly promising materials to modify electrodes and fix aptamers, resulting in a remarkable electrochemical aptasensor for impedimetric sensing of tobramycin (TOB). Nanoscale composites have preferable electroactivity and small particle size with more exposed functional sites, such as Zr­(IV) and −NH2, to immobilize aptamers for enhanced detection performance. As we know, most of the electrochemical impedance aptasensors require a long time to complete the detection process, but this prepared biosensor shows the rapid quantitative identification of target TOB within 4 min. This work expands the synthesis of functional fullerene@metal–organic matrix hybrid materials in electrochemical biosensing applications.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.1c23320