Recent molecular evolution of hepatitis B virus genotype F in Latin America

The evolution of hepatitis B virus genotype F (HBV-F) in Latin America is not completely understood. The aim of this study was to evaluate the molecular evolution of HBV-F in Latin America by comparing 224 whole-genome sequences. Bayesian coalescent analysis was performed to estimate the time to the...

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Bibliographic Details
Published in:Archives of virology 2022-02, Vol.167 (2), p.597-602
Main Authors: Wolf, Jonas Michel, Mazeto, Thiago Kastell, Pereira, Vagner Reinaldo Zingalli Bueno, Simon, Daniel, Lunge, Vagner Ricardo
Format: Article
Language:English
Subjects:
Bayes Theorem
Bayesian analysis
Biomedical and Life Sciences
Biomedicine
Brief Report
Centuries
Dating
Evolution, Molecular
Genomes
Genotype
Genotypes
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B virus - genetics
Humans
Infectious Diseases
Latin America - epidemiology
Medical Microbiology
Minority & ethnic groups
Molecular evolution
Phylogeny
Virology
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Summary:The evolution of hepatitis B virus genotype F (HBV-F) in Latin America is not completely understood. The aim of this study was to evaluate the molecular evolution of HBV-F in Latin America by comparing 224 whole-genome sequences. Bayesian coalescent analysis was performed to estimate the time to the most recent common ancestor. Four main clades were found, dating from between 1245 and 1730. In addition, four subclades were identified, dating to between 1705 and 1801. The overall effective population size of HBV-F grew in the 18th century and showed an initial expansion outward from Venezuela to other countries from Latin America. Although HBV-F originated thousands of years ago, circulating strains of HBV-F appear to have spread in recent centuries, particularly in the 18 th and 19 th centuries. The new molecular data provide valuable information for characterizing the evolution of Native American HBV-F in recent centuries.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-022-05376-z