Bioactive Anti-Inflammatory Thermocatalytic Nanometal-Polyphenol Polypeptide Scaffolds for MRSA-Infection/Tumor Postsurgical Tissue Repair

• Published in: ACS applied materials & interfaces 2022-02, Vol.14 (4), p.4946-4958
• Main Authors: Wang, Yidan, Niu, Wen, Qu, Xiaoyan, Lei, Bo
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biological and Medical Applications of Materials and Interfaces; Catalysis; Cell Line, Tumor; Cell Proliferation - drug effects; Drug Screening Assays, Antitumor; Ferrous Compounds - chemistry; Ferrous Compounds - pharmacology; Humans; Materials Testing; Methicillin-Resistant Staphylococcus aureus - drug effects; Mice; Microbial Sensitivity Tests; Molecular Structure; Particle Size; Peptides - chemistry; Peptides - pharmacology; Polyphenols - chemistry; Polyphenols - pharmacology; Staphylococcal Infections - drug therapy; Surface Properties; Temperature; Tissue Engineering; Tissue Scaffolds - chemistry; Tumor Microenvironment - drug effects; Wound Healing - drug effects
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.1c21082

Postsurgical tumor recurrence, infection, and tissue defect are still the challenges in clinical medicine. The development of multifunctional biomaterial scaffolds with a microenvironment-responsive tumor-infection therapy-tissue repair is highly desirable. Herein, we report a bioactive, injectable, adhesive, self-healing, antibacterial, and anti-inflammatory metal-polyphenol polypeptide nanocomposite scaffold (PEAPF) with temporal–spatial-controlled inflammation-triggered therapeutic properties for efficient infection and postsurgical tumor therapy and skin repair. PEAPF scaffolds showed sustained and inherent inflammation-triggered Fenton catalysis and mild thermochemical effect for specifically inhibiting tumor recurrence in vitro and in vivo. The PEAPF scaffolds significantly facilitated skin tissue regeneration in MRSA-infected chronic wounds and postsurgical tissue defects after tumor resection. This study presents the multifunctional scaffold-based safe and efficient therapeutic strategy to prevent local tumor recurrence and enhance postsurgical tissue regeneration.