Fabrication of a Lignin-Copper Sulfide-Incorporated PVA Hydrogel with Near-Infrared-Activated Photothermal/Photodynamic/Peroxidase-like Performance for Combating Bacteria and Biofilms

Antibiotic-resistant bacteria and biofilms are among the most difficult challenges in infection treatment. Herein, lignin-copper sulfide (LS-CuS) nanocomposites were incorporated into a poly­(vinyl alcohol) (PVA) hydrogel to fabricate a LS-CuS@PVA composite hydrogel with near-infrared-activated phot...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2022-02, Vol.8 (2), p.560-569
Main Authors: Xie, Yuanxiang, Gan, Chuchu, Li, Zhixian, Liu, Weifeng, Yang, Dongjie, Qiu, Xueqing
Format: Article
Language:English
Subjects:
Bacteria
Biofilms
Characterization, Synthesis, and Modifications
Copper - pharmacology
Hydrogels - pharmacology
Hydrogen Peroxide
Lignin - pharmacology
Peroxidase
Sulfides - pharmacology
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Summary:Antibiotic-resistant bacteria and biofilms are among the most difficult challenges in infection treatment. Herein, lignin-copper sulfide (LS-CuS) nanocomposites were incorporated into a poly­(vinyl alcohol) (PVA) hydrogel to fabricate a LS-CuS@PVA composite hydrogel with near-infrared-activated photothermal, photodynamic, and peroxidase-like performance. The antibacterial tests of LS-CuS@PVA exhibited the highest antibacterial rate that caused 3.8-log and 4.8-log reductions of colony forming units (CFUs) against Escherichia coli and Staphylococcus aureus in the presence of H2O2 under near-infrared (NIR) light irradiation for 10 min. The significantly improved bactericidal performance could be attributed to the synergistic effects of hyperthermia and reactive oxygen species (ROS). Furthermore, the LS-CuS@PVA hydrogel could eradicate the already formed biofilm and inhibit biofilm formation. Considering the highly effective antibacterial and antibiofilm activity of the LS-CuS@PVA hydrogel, this work could provide new insights for the design of poly­(vinyl alcohol)-based composite hydrogels for wound healing and wound dressing.
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.1c01406