Evaluation of circulating cell-free nucleic acids in health workers occupationally exposed to ionizing radiation

Radiology workers might constantly be exposed to low-dose ionizing radiation due to their profession. Low doses of radiation in a short exposure time have the potential to alter the genome, which might potentially lead to diseases. The main objective of this study was to determine whether the amount...

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Bibliographic Details
Published in:Environmental science and pollution research international 2022-06, Vol.29 (27), p.40543-40549
Main Authors: Kılınç, Nihal, Onbaşılar, Mehmet, Çayır, Akın
Format: Article
Language:English
Subjects:
Acids
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Cell-Free Nucleic Acids
Computed tomography
Correlation
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Fluoroscopy
Genomes
Health Personnel
Humans
Ionizing radiation
Medical personnel
miRNA
Nucleic acids
Occupational Exposure
Radiation
Radiation dosage
Radiation effects
Radiation measurement
Radiation, Ionizing
Radiography
Radiology
Research Article
Ribonucleic acid
RNA
Tomography
Waste Water Technology
Water Management
Water Pollution Control
Working hours
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Summary:Radiology workers might constantly be exposed to low-dose ionizing radiation due to their profession. Low doses of radiation in a short exposure time have the potential to alter the genome, which might potentially lead to diseases. The main objective of this study was to determine whether the amount of cell-free nucleic acids in plasma samples of radiation-exposed workers was different from the general public, in other words, non-exposed individuals. In this context, we investigated the association between radiation exposure and cell-free nucleic acids concentration by using radiation exposure parameters. The study consisted of 40 radiology workers and 40 individuals who were not exposed to ionizing radiation. The plasma concentrations of cell-free DNA, RNA, and miRNA were measured fluorometrically. We found that the ccfRNA concentration of the radiation-exposed group was significantly different from that of the non-exposed group ( p  = 0.0001). However, there are no differences between both groups in terms of ccfDNA and ccfmiRNA concentration. The concentration of ccfDNA is significantly correlated with working time in the fluoroscopy field ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-022-18828-5