A Nanostructured Phthalocyanine/Albumin Supramolecular Assembly for Fluorescence Turn-On Imaging and Photodynamic Immunotherapy

Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through the self-assembly of morpholine-substituted silicon phthalocyanine (PcM) and albumin. N...

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Bibliographic Details
Published in:ACS nano 2022-02, Vol.16 (2), p.3045-3058
Main Authors: Wang, Rui, Kim, Kyu-Hwan, Yoo, Jiyoon, Li, Xingshu, Kwon, Nahyun, Jeon, Yun-Hui, Shin, Suk-kyung, Han, Seung Seok, Lee, Dong-Sup, Yoon, Juyoung
Format: Article
Language:English
Subjects:
Albumins
Cell Line, Tumor
Fluorescence
Immunotherapy
Isoindoles
Nanostructures
Photochemotherapy - methods
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
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Summary:Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through the self-assembly of morpholine-substituted silicon phthalocyanine (PcM) and albumin. NanoPcM displays a turn-on fluorescence depending on the acid-induced abolition of the photoinduced electron transfer effect (change in molecular structure) and disassembly of the nanostructure (change in supramolecular structure), which enables low-background and tumor-targeted fluorescence imaging. In addition, its efficient type I photoreaction endows NanoPcM with a superior immunogenic photodynamic therapy (PDT) effect against solid tumors. The combination of NanoPcM-based PDT and αPD-1-based immunotherapy can efficiently inhibit tumor growth, reduce spontaneous lung metastasis, and trigger abscopal effects. This study should provide a perspective for the future design of nanomaterials as promising phototheranostics for cancer imaging and therapy.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.1c10565