Increased homocysteine levels correlate with cortical structural damage in Parkinson's disease

• Published in: Journal of the neurological sciences 2022-03, Vol.434, p.120148-120148, Article 120148
• Main Authors: Sampedro, Frederic, Martínez-Horta, Saul, Horta-Barba, Andrea, Grothe, Michel J., Labrador-Espinosa, Miguel A., Jesús, Silvia, Adarmes-Gómez, Astrid, Carrillo, Fátima, Puig-Davi, Arnau, Lora, Florinda Roldán, Barberá, Miquel Aguilar, Pastor, Pau, Arroyo, Sonia Escalante, Vila, Berta Solano, Foraster, Anna Cots, Martínez, Javier Ruiz, Padilla, Francisco Carrillo, Morlans, Mercedes Pueyo, Aramburu, Isabel González, Ceberio, Jon Infante, Vara, Jorge Hernández, de Fábregues-Boixar, Oriol, de Deus Fonticoba, Teresa, Ávila, Asunción, Martínez-Castrillo, Juan Carlos, Bejr-Kasem, Helena, Campolongo, Antonia, Pascual-Sedano, Berta, Martínez-Martín, Pablo, Santos-García, Diego, Mir, Pablo, Kulisevsky, Jaime
• Format: Article
• Language: English
• Subjects: Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Cortical Thinning; Homocysteine; Humans; Magnetic Resonance Imaging; Neuroimaging; Parkinson Disease - complications; Parkinson's disease
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2022.120148

Blood homocysteine appears to be increased in Parkinson's disease (PD) and may play a role in the development and progression of this disorder. However, the specific contribution of abnormal homocysteine levels to cortical degeneration in PD remains elusive. To characterize the cortical structural correlates of homocysteine levels in PD. From the COPPADIS cohort, we identified a subset of PD patients and healthy controls (HC) with available homocysteine and imaging data. Surface-based vertex-wise multiple regression analyses were performed to investigate the cortical macrostructural (cortical thinning) and microstructural (increased intracortical diffusivity) correlates of homocysteine levels in this sample. A total of 137 PD patients and 43 HC were included. Homocysteine levels were increased in the PD group (t = −2.2, p = 0.03), correlating in turn with cognitive performance (r = −0.2, p = 0.03). Homocysteine in PD was also associated with frontal cortical thinning and, in a subset of patients with available DTI data, with microstructural damage in frontal and posterior-cortical regions (p