Development and autoregulation of kidney function in children: a retrospective study using 99mTc-MAG3 renography

• Published in: Pediatric nephrology (Berlin, West) West), 2022-09, Vol.37 (9), p.2157-2166
• Main Authors: Cao, Xinhua, Xu, Xiaoyin, Treves, S. Ted, Drubach, Laura A., Kwatra, Neha, Zhang, Min, Fahey, Frederic H., Diamond, David A., Voss, Stephan D.
• Format: Article
• Language: English
• Subjects: Children; Kidneys; Medicine; Medicine & Public Health; Nephrology; Original Article; Patients; Pediatrics; Urology; What’s new in Renal Development
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-022-05446-z

Background Both the development of kidney function in healthy children and autoregulation ability of kidney function in patients with asymmetric kidneys are important in clinical diagnosis and treatment of kidney-related diseases, but there are however only limited studies. This study aimed to investigate development of kidney function in normal children with healthy symmetric kidneys and autoregulation of the healthy kidney compensating the functional loss of a diseased one in children with asymmetric kidneys. Methods Two hundred thirty-seven children (156 male, 81 female) from 0 to 20y (average 4.6y ± 5.1) undergoing 99m Tc-MAG3 renography were included, comprising 134 with healthy symmetrically functioning kidneys and 103 with asymmetric kidneys. Clearance was calculated from kidney uptakes at 1–2 min. A developmental model between MAG3 clearance (CL) and patient age in normal group was identified (CL  =  84.39Age 0.395  ml/min, r  = 0.957 , p