High normal sized CGG repeat on the FMR1 gene reduces live birth rates after in vitro fertilization in Han Chinese

•Women with high normal FMR1 allele have a higher risk of reduced live birth rates.•Enhanced screening for fragile X syndrome in women of childbearing age in China.•Association between the FMR1 genotype and fertility merits further research. Substantial evidence now suggests an association between t...

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Bibliographic Details
Published in:Gene 2022-04, Vol.819, p.146204-146204, Article 146204
Main Authors: Zhou, Xuanyou, Shi, Weihui, Ye, Mujin, Chen, Songchang, Xu, Naixin, Xu, Chenming
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - genetics
Adult
Alleles
Asians - genetics
Female
Fertilization in Vitro
FMR1 gene
Fragile X Mental Retardation Protein - genetics
Fragile X screening
Fragile X Syndrome - genetics
FXPOI
Genetic Association Studies
Genetic Testing - methods
Humans
IVF
Live Birth - genetics
Pregnancy
Reproductive failure
Reproductive Medicine
Retrospective Studies
Trinucleotide Repeats
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Summary:•Women with high normal FMR1 allele have a higher risk of reduced live birth rates.•Enhanced screening for fragile X syndrome in women of childbearing age in China.•Association between the FMR1 genotype and fertility merits further research. Substantial evidence now suggests an association between the FMR1 genotype and female fertility. The aim of this study was to determine whether a high normal FMR1 allele (35–54 repeats) affects in vitro fertilization (IVF) outcomes in Chinese women. A total of 120 women with 210 IVF cycles were retrospectively recruited in this study. The patients were divided into two groups based on the FMR1 repeat lengths at allele 2 (normal repeat group:
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2022.146204