Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment

Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel...

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Bibliographic Details
Published in:Nanotechnology 2022-05, Vol.33 (20), p.205101
Main Authors: Pinheiro, Willie Oliveira, Costa do Santos, Mayara Simonelly, Farias, Gabriel Ribeiro, Fascineli, Maria Luiza, Ramos, Khellida Loiane Vieira, Duarte, Eliza Carla Barroso, Damasceno, Emanuel Adelino Medeiros, da Silva, Jaqueline Rodrigues, Joanitti, Graziella Anselmo, de Azevedo, Ricardo Bentes, Sousa, Marcelo Henrique, Lacava, Zulmira Guerrero Marques, Mosiniewicz-Szablewska, Ewa, Suchocki, Piotr, Morais, Paulo Cesar, de Andrade, Laise Rodrigues
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Carcinoma, Ehrlich Tumor - pathology
Carcinoma, Ehrlich Tumor - therapy
Cell Cycle - drug effects
Combined Modality Therapy
DNA Fragmentation - drug effects
Ehrlich tumor
elderly mice
Female
Hyperthermia, Induced
maghemite nanoparticles
magnetic hyperthermia
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - therapeutic use
Magnetite Nanoparticles - ultrastructure
mathematical modeling
Mice
Nanocapsules - chemistry
Nanocapsules - therapeutic use
Nanocapsules - ultrastructure
Selenium Compounds - chemistry
Selenium Compounds - therapeutic use
selol-loaded PLGA-nanocapsule
Time Factors
Treatment Outcome
Tumor Burden - drug effects
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Summary:Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel and MHT, separately or combined. The time evolution of the tumor volume is successfully modeled using the logistic mathematical model. The combined therapy comprising NcSel and MHT is able to hinder primary tumor growth and a case of complete tumor remission is recorded. Moreover, no metastasis was diagnosed and the adverse effects are negligible. NcSel plus MHT may represent an effective and safe alternative to cancer control in aged patients. Future clinical trials are encouraged.
ISSN:0957-4484
1361-6528
DOI:10.1088/1361-6528/ac504c