Echocardiographic assessment of intimal thickness growth of patent ductus arteriosus in neonates and analysis of influencing factors

The spontaneous closure rate of patent ductus arteriosus (PDA) is high, and the necessity of early intervention is debated. Quantitative echocardiographic assessment of the intima in PDA has not been reported. This study evaluated intimal thickness growth in neonatal cases of PDA via echocardiograph...

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Bibliographic Details
Published in:The international journal of cardiovascular imaging 2022-07, Vol.38 (7), p.1443-1452
Main Authors: Hu, Xin-Lu, Wang, Hui, Hou, Cui, Hou, Miao, Zhan, Shi-Hong, Pan, Tao, Ding, Yue-Yue, Gu, Pei-Pei, Xu, Qiu-Qin
Format: Article
Language:English
Subjects:
Birth
Cardiac Imaging
Cardiology
Congenital diseases
Coronary vessels
Decision making
Diameters
Early intervention
Echocardiography
Gestational age
Growth rate
Imaging
Medicine
Medicine & Public Health
Neonates
Original Paper
Oxygen demand
Radiology
Thickness
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Summary:The spontaneous closure rate of patent ductus arteriosus (PDA) is high, and the necessity of early intervention is debated. Quantitative echocardiographic assessment of the intima in PDA has not been reported. This study evaluated intimal thickness growth in neonatal cases of PDA via echocardiography and investigated its correlation with clinical factors. Seventy-three neonates were enrolled, and echocardiography was performed three times: within 24 h post-birth (first echo), 48 h after the first echo (second echo), and before discharge (third echo). According to PDA outcome, the neonates were divided into the PDA-open group (n = 18 cases), PDA-closure at second echo group (n = 32 cases), and non-PDA at first echo group (n = 23 cases). We measured the intimal thickness (IT1 and IT2 at first and second echo, respectively), lumen diameter of ductus arteriosus (D1 and D2 at first and second echo, respectively), IT1/D1 ratio, and intimal thickness growth rate (V). Correlations between echocardiographic indicators, perinatal factors, and clinical treatment were analyzed. On first echo, the PDA-open group showed a significantly lower IT1/D1 than the combined PDA-closure group (P 
ISSN:1875-8312
1569-5794
1875-8312
1573-0743
DOI:10.1007/s10554-022-02531-0