An update on the roles of circular RNAs in spinal cord injury

Spinal cord injury (SCI) is a disabling condition for which therapeutic options are limited. Increasing number of microarray and next-generation sequencing studies have demonstrated that SCI coincides with altered expression of circular RNAs (circRNAs) in the damaged tissue. Emerging functional evid...

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Bibliographic Details
Published in:Molecular neurobiology 2022-04, Vol.59 (4), p.2620-2628
Main Authors: Ma, Xuezhen, Wang, Xuesong, Ma, Xuexiao, Zhang, Xiugong, Gong, Xiaojin, Sun, Ruifu, Wong, Sunny H., Chan, Matthew T. V., Wu, William Ka Kei
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Biomedical and Life Sciences
Biomedicine
Cell Biology
Gene Regulatory Networks
Humans
Inflammation
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Neurobiology
Neurology
Neurosciences
Next-generation sequencing
Regeneration
RNA, Circular - genetics
Spinal cord injuries
Spinal Cord Injuries - genetics
Spinal Cord Injuries - metabolism
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Summary:Spinal cord injury (SCI) is a disabling condition for which therapeutic options are limited. Increasing number of microarray and next-generation sequencing studies have demonstrated that SCI coincides with altered expression of circular RNAs (circRNAs) in the damaged tissue. Emerging functional evidence further pinpointed specific differentially expressed circRNAs (e.g., circ-HIPK3, cicRNA.7079, circRNA_01477, circRNA-2960, and circ_0001723 ) for their effects on cellular processes relevant to SCI repair and regeneration, including neuronal apoptosis, astrocyte activation, and neuroinflammation, via sponging SCI-related microRNAs. Although circRNAs and their target microRNAs appear to be good candidates for therapeutic exploitation in SCI, further investigation into the efficient delivery of these regulatory molecules in a cell-type specific manner is a pre-requisite for translating these basic discoveries into clinical benefits.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-021-02721-2