Negative pressure wound therapy versus conventional wound care in cancer surgical wounds: A meta‐analysis of observational studies and randomised controlled trials

The application of negative pressure wound therapy (NPWT) in cancer surgical wounds is still controversial, despite its promising usage, because of the risks of increased tumorigenesis and metastasis. This study aimed to review the risks and benefits of NPWT in surgical wounds with the underlying ma...

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Bibliographic Details
Published in:International wound journal 2022-10, Vol.19 (6), p.1578-1593
Main Authors: Putri, Indri Lakhsmi, Adzalika, Lavonia Berlina, Pramanasari, Rachmaniar, Wungu, Citrawati Dyah Kencono
Format: Article
Language:English
Subjects:
Cancer therapies
cancer wound
Cervical cancer
Chemotherapy
Colorectal cancer
Contraindications
Disease
Fallopian tubes
Genital cancers
Hysterectomy
Laparotomy
Lymphatic system
malignant wound
Mastectomy
medical care
Melanoma
negative pressure wound therapy
Observational studies
Ostomy
Ovarian cancer
Pancreatic cancer
Pancreaticoduodenectomy
Peritoneal cancer
Radiation therapy
Surgery
Surgical outcomes
Uterine cancer
vacuum‐assisted closure
Wound dehiscence
Wound healing
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Summary:The application of negative pressure wound therapy (NPWT) in cancer surgical wounds is still controversial, despite its promising usage, because of the risks of increased tumorigenesis and metastasis. This study aimed to review the risks and benefits of NPWT in surgical wounds with the underlying malignant disease compared with conventional wound care (CWC). The first outcome was wound complications, divided into surgical site infection (SSI), seroma, hematoma, and wound dehiscence. The secondary outcome was hospital readmission. We performed a separate meta‐analysis of observational studies and randomised controlled trials (RCTs) with CI 95%. Thirteen observational studies with 1923 patients and seven RCTs with 1091 patients were included. NPWT group showed significant decrease in the risk of SSI (RR = 0.45) and seroma (RR = 0.61) in observational studies with P value
ISSN:1742-4801
1742-481X
DOI:10.1111/iwj.13756