Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder

• Published in: Progress in neuro-psychopharmacology & biological psychiatry 2022-06, Vol.116, p.110516-110516, Article 110516
• Main Authors: Tomiyama, Hirofumi, Murayama, Keitaro, Nemoto, Kiyotaka, Hasuzawa, Suguru, Mizobe, Taro, Kato, Kenta, Matsuo, Akira, Ohno, Aikana, Kang, Mingi, Togao, Osamu, Hiwatashi, Akio, Ishigami, Kousei, Nakao, Tomohiro
• Format: Article
• Language: English
• Subjects: And front-parietal network; Brain Mapping; Cingulo-opercular salience network; Cortico-striato-thalamo-cortical circuit; Default mode network; Endophenotypes; Gyrus Cinguli - diagnostic imaging; Humans; Magnetic Resonance Imaging; Neural Pathways - diagnostic imaging; Obsessive-compulsive disorder; Obsessive-Compulsive Disorder - diagnostic imaging; Obsessive-Compulsive Disorder - genetics; Resting state functional MRI; Thalamus
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2022.110516

Background It is gradually becoming clear that obsessive-compulsive disorder (OCD) patients have aberrant resting-state large-scale intrinsic networks of cingulo-opercular salience (SN), default mode (DMN), and front-parietal network (FPN). However, it remains unknown whether unaffected first-degree relatives of OCD patients have these alterations as a vulnerability marker to the disorder. Methods We performed resting-state functional magnetic resonance imaging (rsfMRI) scans of 47 medication-free OCD patients, 21 unaffected healthy first-degree relatives of OCD patients, and 62 healthy control (HC) participants. We explored differences between the three groups in the functional connectivity from SN (seeds: anterior-insula (AI) and dorsal anterior cingulate cortex (dACC)), DMN (seeds: medial prefrontal cortex (MPFC) and posterior parietal cortex (PCC)), and FPN (seeds: dorsolateral prefrontal cortex (DLPFC)). Results Compared to HC, both OCD patients and first-degree relatives showed significantly greater functional connectivity between AI and PCC and between DLPFC and the thalamus. Compared to first-degree relatives and HC, OCD patients showed reduced functional connectivity between PCC and DLPFC, and this altered functional connectivity was negatively correlated with anxiety and depressive symptom within OCD group. Conclusions OCD patients and unaffected first-degree relatives of OCD patients showed overlapping alterations in resting state functional connectivity between the regions of SN and DMN and between DLPFC and the thalamus. Our results suggested that alterations between large-scale intrinsic networks and within the dorsal cognitive cortico-striato-thalamo-cortical (CSTC) circuit could represent endophenotype markers of OCD. •OCD patients have alterations of cortico-striato-thalamo-cortical circuits.•OCD patients have alterations of default mode and cingulo-opercular salience network.•First-degree relatives also have overlapping alteration in these networks.•Alteration of these networks may be an endophenotype markers of OCD.